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In 46 children with uCP (mean\u00a0age\u00a0=\u00a010\u2009years 7\u2009months\u2009\u00b1\u20092\u2009years 9\u2009months; Manual Ability Classification System I\u00a0=\u00a015, II\u00a0=\u00a016, III\u00a0=\u00a015)\u00a0we assessed upper limb somatosensory and motor function. We collected multi\u2010shell diffusion\u2010weighted, T1\u2010weighted and T2\u2010FLAIR MRI and identified the corticospinal tract (CST) wiring pattern using transcranial magnetic stimulation. Structural connectomes were constructed using Virtual Brain Grafting\u2010modified FreeSurfer parcellations and multi\u2010shell multi\u2010tissue constrained spherical deconvolution\u2010based anatomically\u2010constrained tractography. Graph metrics (characteristic path length, global\/local efficiency and clustering coefficient) of the whole brain, the ipsilesional\/contralesional hemisphere, and the full\/ipsilesional\/contralesional sensory\u2010motor network were compared between lesion types (periventricular white matter (PWM)\u00a0=\u00a028, cortical and deep gray matter (CDGM)\u00a0=\u00a018) and CST\u2010wiring patterns (ipsilateral\u00a0=\u00a014, bilateral\u00a0=\u00a014, contralateral\u00a0=\u00a012, unknown\u00a0=\u00a06) using ANCOVA with age as covariate. Using elastic\u2010net regularized regression we investigated how graph metrics, lesion volume, lesion type, CST\u2010wiring pattern and age predicted sensory\u2010motor function. In both the whole brain and subnetworks, we observed a hyperconnectivity pattern in children with CDGM\u2010lesions compared with PWM\u2010lesions, with higher clustering coefficient (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0[&lt;.001\u2013.047], =[0.09\u20130.27]), characteristic path length (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.003, =0.19) and local efficiency (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0[.001\u2013.02], =[0.11\u20130.21]), and a lower global efficiency with age (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0[.01\u2013.04], =[0.09\u20130.15]). No differences were found between CST\u2010wiring groups. Overall, good predictions of sensory\u2010motor function were obtained with elastic\u2010net regression (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a0.40\u2013.87). CST\u2010wiring pattern was the strongest predictor for motor function. For somatosensory function, all independent variables contributed equally to the model. In\u00a0conclusion, we demonstrated the potential of structural connectomics in understanding disease severity and brain development in children with uCP.\n                  <\/jats:p>","DOI":"10.1002\/hbm.26241","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T11:43:37Z","timestamp":1677325417000},"page":"2741-2753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring structural connectomes in children with unilateral cerebral palsy using graph theory"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-548X","authenticated-orcid":false,"given":"Ahmed","family":"Radwan","sequence":"first","affiliation":[{"name":"Leuven Brain Institute KU Leuven  Leuven Belgium"},{"name":"Department of Imaging &amp; Pathology KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-7027","authenticated-orcid":false,"given":"Lisa","family":"Decraene","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences KU Leuven  Leuven Belgium"},{"name":"Rehabilitation Research Centre (REVAL), Faculty of Rehabilitation Sciences Hasselt University  Diepenbeek Belgium"},{"name":"KU Leuven Child &amp; Youth Institute  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1980-2540","authenticated-orcid":false,"given":"Patrick","family":"Dupont","sequence":"additional","affiliation":[{"name":"Leuven Brain Institute KU Leuven  Leuven Belgium"},{"name":"Department of Neurosciences, Lab for Cognitive Neurology KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2421-6845","authenticated-orcid":false,"given":"Nicolas","family":"Leenaerts","sequence":"additional","affiliation":[{"name":"Leuven Brain Institute KU Leuven  Leuven Belgium"},{"name":"Department of Neurosciences, Mind\u2010Body Research KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Simon\u2010Martinez","sequence":"additional","affiliation":[{"name":"Institute of Information Systems University of Applied Sciences Western Switzerland (HES\u2010SO) Valais\u2010Wallis  Sierre Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrijn","family":"Klingels","sequence":"additional","affiliation":[{"name":"Rehabilitation Research Centre (REVAL), Faculty of Rehabilitation Sciences Hasselt University  Diepenbeek Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"Ortibus","sequence":"additional","affiliation":[{"name":"KU Leuven Child &amp; Youth Institute  Leuven Belgium"},{"name":"Department of Development and Regeneration KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde","family":"Feys","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences KU Leuven  Leuven Belgium"},{"name":"KU Leuven Child &amp; Youth Institute  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-4680","authenticated-orcid":false,"given":"Stefan","family":"Sunaert","sequence":"additional","affiliation":[{"name":"Leuven Brain Institute KU Leuven  Leuven Belgium"},{"name":"Department of Imaging &amp; Pathology KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4746-9688","authenticated-orcid":false,"given":"Jeroen","family":"Blommaert","sequence":"additional","affiliation":[{"name":"Leuven Brain Institute KU Leuven  Leuven Belgium"},{"name":"KU Leuven Child &amp; Youth Institute  Leuven Belgium"},{"name":"Department of Oncology KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-098X","authenticated-orcid":false,"given":"Lisa","family":"Mailleux","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences KU Leuven  Leuven Belgium"},{"name":"KU Leuven Child &amp; Youth Institute  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00336-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14184.Reliability"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4717"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.025.A"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23686"},{"key":"e_1_2_9_7_1","unstructured":"Bhushan C. 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