{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:32Z","timestamp":1786977932079,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017616","name":"Beijing Talents Fund","doi-asserted-by":"publisher","award":["2017000021469G211"],"award-info":[{"award-number":["2017000021469G211"]}],"id":[{"id":"10.13039\/501100017616","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Brain arteriovenous malformations (AVMs) may involve language areas but usually do not lead to aphasia. This study evaluated resting\u2010state functional alterations and investigated the language reorganization mechanism in AVM patients. Thirty\u2010nine patients with AVMs involving language areas and 32 age\u2010 and sex\u2010matched healthy controls were prospectively enrolled. The AVM patients were categorized into three subgroups according to lesion location: the frontal (15 patients), temporal (14 patients), and parietal subgroups (10 patients). All subjects underwent resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI), and the amplitude of low\u2010frequency fluctuation (ALFF) approach was applied to analyze rs\u2010fMRI data. Language abilities were normal in all participants based on the Western Aphasia Battery. Compared with those of healthy subjects, ALFF values significantly increased (FDR corrected\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01) in the anterior part of the right putamen in the frontal AVM subgroup, in the posterior part of the right inferior and middle temporal gyrus in the temporal AVM subgroup, and in the inferior lateral part of the left cerebellar hemisphere (lobule VIII) and the right inferior parietal lobule in the parietal AVM subgroup. Functional annotation using Neurosynth indicated that the ALFF t\u2010map was only significantly positively associated with the language\u2010related domain (FDR corrected\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01). In patients with AVMs involving the language cortex, language network reorganization occurs to maintain normal language abilities. The brain areas recruited into the reorganized language network were located in the right cerebral and left cerebellar hemispheres, both of which are nondominant hemispheres. Differences in lesion location led to distinct reorganization patterns.\n                  <\/jats:p>","DOI":"10.1002\/hbm.26245","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T04:28:51Z","timestamp":1677990531000},"page":"2790-2801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Resting\u2010state functional alterations in patients with brain arteriovenous malformations involving language areas"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4531-7760","authenticated-orcid":false,"given":"Xiaofeng","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders  Beijing 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