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The study aims to explore how white matter structure changes in particular OCD symptom dimensions. Prior studies attempt to find the correlation between Y\u2010BOCS scores and OCD patients. However, in this study, we separated the contamination subgroup in OCD and compared directly to healthy control to find regions that exactly related to contamination symptoms. To evaluate structural alterations, diffusion tensor imaging was acquired from 30 OCD patients and 34 demographically matched healthy controls. Data were processed using tract\u2010based spatial statistics (TBSS) analysis. First, by comparing all OCD to healthy controls, significant fractional anisotropy (FA) decreased in the right anterior thalamic radiation, right corticospinal tract, and forceps minor observed. Then by comparing the contamination subgroup to healthy control, FA decreases in the forceps minor region. Consequently, forceps minor plays a central role in the pathophysiology of contamination behaviors. Finally, other subgroups were compared to healthy control and discovered that FA in the right corticospinal tract and right anterior thalamic radiation is reduced.<\/jats:p>","DOI":"10.1002\/hbm.26282","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T14:15:20Z","timestamp":1679926520000},"page":"3302-3310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Relationship between white matter alterations and contamination subgroup in obsessive compulsive disorder: A <scp>diffusion tensor imaging<\/scp> study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9290-3601","authenticated-orcid":false,"given":"Mahvash","family":"Azarvand Damirichi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Health, Tehran Medical Sciences Islamic Azad University  Tehran 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