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However, how these areas interact during visual perception and imagery of scenes, especially when recollecting their spatial location, remains unknown. Here, we combined functional magnetic resonance imaging (fMRI), resting\u2010state functional connectivity (rs\u2010fc), and effective connectivity to assess spontaneous fluctuations and task\u2010induced modulation of signals among regions entailing scene\u2010processing, the primary visual area and the hippocampus (HC), responsible for the retrieval of stored information. First, we functionally defined the scene\u2010selective regions, that is, the occipital place area (OPA), the retrosplenial complex (RSC) and the parahippocampal place area (PPA), by using the face\/scene localizer, observing that two portions of the PPA\u2014anterior and posterior PPA\u2014were consistently activated in all subjects. Second, the rs\u2010fc analysis (<jats:italic>n<\/jats:italic>\u2009=\u200977) revealed a connectivity pathway similar to the one described in macaques, showing separate connectivity routes linking the anterior PPA with RSC and HC, and the posterior PPA with OPA. Third, we used dynamic causal modelling to evaluate whether the dynamic couplings among these regions differ between perception and imagery of familiar landmarks during a fMRI task (<jats:italic>n<\/jats:italic>\u2009=\u200916). We found a positive effect of HC on RSC during the retrieval of imagined places and an effect of occipital regions on both RSC and pPPA during the perception of scenes. Overall, we propose that under similar functional architecture at rest, different neural interactions take place between regions in the occipito\u2010temporal higher\u2010level visual cortex and the HC, subserving scene perception and imagery.<\/jats:p>","DOI":"10.1002\/hbm.26313","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T15:30:35Z","timestamp":1684855835000},"page":"3954-3971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Preferential signal pathways during the perception and imagery of familiar scenes: An effective connectivity study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2327-2063","authenticated-orcid":false,"given":"Maria Giulia","family":"Tullo","sequence":"first","affiliation":[{"name":"Department of Translational and Precision Medicine Sapienza University  Rome Italy"},{"name":"Brain Imaging Laboratory, Department 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