{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:55:20Z","timestamp":1768809320755,"version":"3.49.0"},"reference-count":65,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SWU119007"],"award-info":[{"award-number":["SWU119007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071070"],"award-info":[{"award-number":["32071070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2019jcyj\u2010msxmX0520"],"award-info":[{"award-number":["cstc2019jcyj\u2010msxmX0520"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2020jcyj\u2010msxmX0299"],"award-info":[{"award-number":["cstc2020jcyj\u2010msxmX0299"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cognitive and behavioral development of children and adolescents is closely related to the maturation of brain morphology. Although the trajectory of brain development has been depicted in detail, the underlying biological mechanism of normal cortical morphological development in childhood and adolescence remains unclear. By combining the Allen Human Brain Atlas dataset with two single\u2010site magnetic resonance imaging data including 427 and 733 subjects from China and the United States, respectively, we performed partial least squares regression and enrichment analysis to explore the relationship between the gene transcriptional expression and the development of cortical thickness in childhood and adolescence. We found that the spatial model of normal cortical thinning during childhood and adolescence is associated with genes expressed predominantly in astrocytes, microglia, excitatory and inhibitory neurons. Top cortical development\u2010related genes are enriched for energy\u2010related and DNA\u2010related terms and are associated with psychological and cognitive disorders. Interestingly, there is a great deal of similarity between the findings derived from the two single\u2010site datasets. This fills the gap between early cortical development and transcriptomes, which promotes an integrative understanding of the potential biological neural mechanisms.<\/jats:p>","DOI":"10.1002\/hbm.26328","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T17:31:07Z","timestamp":1683307867000},"page":"4040-4051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gene transcriptional expression of cortical thinning during childhood and adolescence"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2540-4595","authenticated-orcid":false,"given":"Zheyi","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology Southwest University  Chongqing China"},{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2544-8015","authenticated-orcid":false,"given":"Dongtao","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology Southwest University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Psychology Central China Normal University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology Southwest University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaozheng","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University  Beijing China"},{"name":"Beijing Key Laboratory of Brain Imaging and Connectomics Beijing Normal University  Beijing China"},{"name":"IDG\/McGovern Institute for Brain Research Beijing Normal University  Beijing China"},{"name":"Chinese Institute for Brain Research  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education (BNU), Faculty of Psychology Beijing Normal University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9110-585X","authenticated-orcid":false,"given":"Xi\u2010Nian","family":"Zuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University  Beijing China"},{"name":"IDG\/McGovern Institute for Brain Research Beijing Normal University  Beijing China"},{"name":"National Basic Science Data Center  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010Jia","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University  Beijing China"},{"name":"Shenzhen Key Laboratory of Affective and Social Neuroscience, Magnetic Resonance Imaging Center, Center for Brain Disorders and Cognitive Sciences Shenzhen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0269-5910","authenticated-orcid":false,"given":"Jiang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology Southwest University  Chongqing China"},{"name":"Southwest University Branch, Collaborative Innovation Center of Assessment Toward Basic Education Quality Beijing Normal University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.036"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/wics.51"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2017.181"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.02.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu214"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139516"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.041"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116803"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.194183"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.295"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.02.013"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04554-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw303"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002622"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010356107"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507125112"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5216-08.2009"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/271115a0"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200033797"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.11.024"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.034"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(94)00015-H"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00045"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10964-012-9759-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4407"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11405"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001229107"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z"},{"key":"e_1_2_9_33_1","first-page":"690","article-title":"Neurodevelopmental behavioral and cognitive disorders","volume":"21","author":"Jeste S. S.","year":"2015","journal-title":"Continuum"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.12.023"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.014"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4038"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90500-2"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21943-5"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat7615"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2021.101020"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608282113"},{"key":"e_1_2_9_42_1","article-title":"Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia\u2010related genes","volume":"116","author":"Morgan S.","year":"2019","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0621-y"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2307\/1130498"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-007-9100-0"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2020.8"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp026"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3708"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.086"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.12.005"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.016"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17051-5"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx197"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2018.51.11.226"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-396481-6.00023-4"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3302-16.2017"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17010100"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx249"},{"key":"e_1_2_9_59_1","first-page":"1472","article-title":"Through thick and thin: A need to reconcile contradictory results on trajectories in human cortical development","volume":"27","author":"Walhovd K. B.","year":"2017","journal-title":"Cerebral Cortex"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601745113"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.2694"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1360\/N972017-00362"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obhdp.2016.05.003"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.013"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2016.10.005"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T21:43:20Z","timestamp":1692222200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.26328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,5]]},"references-count":65,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/hbm.26328"],"URL":"https:\/\/doi.org\/10.1002\/hbm.26328","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,5]]},"assertion":[{"value":"2023-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}