{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:35:41Z","timestamp":1789137341586,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019192","name":"UAB Center for Clinical and Translational Science","doi-asserted-by":"publisher","award":["UL1TR000165"],"award-info":[{"award-number":["UL1TR000165"]}],"id":[{"id":"10.13039\/100019192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Late\u2010stage macular degeneration (MD) often causes retinal lesions depriving an individual of central vision, forcing them to learn to use peripheral vision for daily tasks. To compensate, many patients develop a preferred retinal locus (PRL), an area of peripheral vision used more often than equivalent regions of spared vision. Thus, associated portions of cortex experience <jats:italic>increased<\/jats:italic> use, while portions of cortex associated with the lesion are <jats:italic>deprived<\/jats:italic> of sensory input. Prior research has not well examined the degree to which structural plasticity depends on the amount of use across the visual field. Cortical thickness, neurite density, and orientation dispersion were measured at portions of cortex associated with the PRL, the retinal lesion, and a control region in participants with MD as well as age\u2010matched, gender\u2010matched, and education\u2010matched controls. MD participants had significantly thinner cortex in both the cortical representation of the PRL (cPRL) and the control region, compared with controls, but no significant differences in thickness, neurite density, or orientation dispersion were found between the cPRL and the control region as functions of disease or onset. This decrease in thickness is driven by a subset of early\u2010onset participants whose patterns of thickness, neurite density, and neurite orientation dispersion are distinct from matched control participants. These results suggest that people who develop MD earlier in adulthood may undergo more structural plasticity than those who develop it late in life.<\/jats:p>","DOI":"10.1002\/hbm.26334","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T12:45:53Z","timestamp":1684327553000},"page":"4120-4135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cortical plasticity in central vision loss: Cortical thickness and neurite structure"],"prefix":"10.1002","volume":"44","author":[{"given":"Matthew K.","family":"Defenderfer","sequence":"first","affiliation":[{"name":"Civitan International Research Center University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Department of Neurobiology, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7159-5457","authenticated-orcid":false,"given":"Pinar","family":"Demirayak","sequence":"additional","affiliation":[{"name":"Civitan International Research Center University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Department of Neurobiology, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leland L.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Civitan International Research Center University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Department of Neurobiology, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn K.","family":"DeCarlo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Stewart","sequence":"additional","affiliation":[{"name":"Civitan International Research Center University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Department of Neurobiology, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0737-4024","authenticated-orcid":false,"given":"Kristina M.","family":"Visscher","sequence":"additional","affiliation":[{"name":"Civitan International Research Center University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Department of Neurobiology, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00336-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2008.05.020"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3476-04.2005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2793"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116670"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003538"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.09.014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.40224"},{"key":"e_1_2_9_11_1","first-page":"135","article-title":"Fundus flavimaculatus","author":"Blacharski P. 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