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Previous research has shown dynamic changes in the brain prior to tic onset leading to tics, and this study aims to investigate the contribution of network dynamics to them. For this, we have employed three methods of functional connectivity to resting\u2010state fMRI data \u2013 namely the static, the sliding window dynamic and the ICA based estimated dynamic; followed by an examination of the static and dynamic network topological properties. A leave\u2010one\u2010out (LOO\u2010) validated regression model with LASSO regularization was used to identify the key predictors. The relevant predictors pointed to dysfunction of the primary motor cortex, the prefrontal\u2010basal ganglia loop and amygdala\u2010mediated visual social processing network. This is in line with a recently proposed social decision\u2010making dysfunction hypothesis, opening new horizons in understanding tic pathophysiology.<\/jats:p>","DOI":"10.1002\/hbm.26341","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T07:50:20Z","timestamp":1685087420000},"page":"4225-4238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["How brain networks tic: Predicting tic severity through\n                    <scp>rs\u2010fMRI<\/scp>\n                    dynamics in\n                    <scp>Tourette<\/scp>\n                    syndrome"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-1873","authenticated-orcid":false,"given":"Shukti","family":"Ramkiran","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and Medicine 4 (INM\u20104) Forschungszentrum Juelich  Juelich Germany"},{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University  Aachen Germany"},{"name":"JARA \u2013 BRAIN \u2013 Translational Medicine  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Veselinovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine 4 (INM\u20104) Forschungszentrum Juelich  Juelich Germany"},{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Dammers","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine 4 (INM\u20104) Forschungszentrum Juelich  Juelich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnim Johannes","family":"Gaebler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University  Aachen Germany"},{"name":"JARA \u2013 BRAIN \u2013 Translational Medicine  Aachen Germany"},{"name":"Institute of Physiology, Faculty of Medicine RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-5316","authenticated-orcid":false,"given":"Ravichandran","family":"Rajkumar","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine 4 (INM\u20104) Forschungszentrum Juelich  Juelich Germany"},{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University  Aachen Germany"},{"name":"JARA \u2013 BRAIN \u2013 Translational Medicine  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-6169","authenticated-orcid":false,"given":"N. 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