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Functional neuroimaging research, including functional connectivity (FC) using resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI), has identified neural aberrations related to HIV infection. Yet little is known about the relationship between aging and resting\u2010state FC in PWH. This study included 86 virally suppressed PWH and 99 demographically matched controls spanning 22\u201372\u2009years old who underwent rs\u2010fMRI. The independent and interactive effects of HIV and aging on FC were investigated both within\u2010 and between\u2010network using a 7\u2010network atlas. The relationship between HIV\u2010related cognitive deficits and FC was also examined. We also conducted network\u2010based statistical analyses using a brain anatomical atlas (<jats:italic>n<\/jats:italic>\u2009=\u2009512 regions) to ensure similar results across independent approaches. We found independent effects of age and HIV in between\u2010network FC. The age\u2010related increases in FC were widespread, while PWH displayed further increases above and beyond aging, particularly between\u2010network FC of the default\u2010mode and executive control networks. The results were overall similar using the regional approach. Since both HIV infection and aging are associated with independent increases in between\u2010network FC, HIV infection may be associated with a reorganization of the major brain networks and their functional interactions in a manner similar to aging.<\/jats:p>","DOI":"10.1002\/hbm.26409","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T13:24:28Z","timestamp":1688736268000},"page":"4679-4691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Resting state network connectivity alterations in <scp>HIV<\/scp>: Parallels with aging"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-4993","authenticated-orcid":false,"given":"Brandon J.","family":"Lew","sequence":"first","affiliation":[{"name":"Institute for Human Neuroscience Boys Town National Research Hospital  Omaha Nebraska USA"},{"name":"College of Medicine University of Nebraska Medical 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