{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:54:30Z","timestamp":1791618870749,"version":"4.3.4"},"reference-count":75,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014405","name":"Centre for Addiction and Mental Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["P50MH080173"],"award-info":[{"award-number":["P50MH080173"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["1\/3 R01 MH102324"],"award-info":[{"award-number":["1\/3 R01 MH102324"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH102313"],"award-info":[{"award-number":["R01MH102313"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2P50AA012870\u201011"],"award-info":[{"award-number":["2P50AA012870\u201011"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01MH108590"],"award-info":[{"award-number":["5R01MH108590"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01MH112189"],"award-info":[{"award-number":["5R01MH112189"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U01MH121766"],"award-info":[{"award-number":["1U01MH121766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP5OD012109"],"award-info":[{"award-number":["DP5OD012109"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spatial patterns of brain functional connectivity can vary substantially at the individual level. Applying cortical surface\u2010based approaches with individualized rather than group templates may accelerate the discovery of biological markers related to psychiatric disorders. We investigated cortico\u2010subcortical networks from multi\u2010cohort data in people with schizophrenia spectrum disorders (SSDs) and healthy controls (HC) using individualized connectivity profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We utilized resting\u2010state and anatomical MRI data from\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009406 participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009203 SSD,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009203 HC) from four cohorts. Functional timeseries were extracted from previously defined intrinsic network subregions of the striatum, thalamus, and cerebellum as well as 80 cortical regions of interest, representing six intrinsic networks using (1) volume\u2010based approaches, (2) a surface\u2010based group atlas approaches, and (3) Personalized Intrinsic Network Topography (PINT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The correlations between all cortical networks and the expected subregions of the striatum, cerebellum, and thalamus were increased using a surface\u2010based approach (Cohen's\n                      <jats:italic>D<\/jats:italic>\n                      volume vs. surface 0.27\u20131.00, all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u200910\n                      <jats:sup>\u22126<\/jats:sup>\n                      ) and further increased after PINT (Cohen's\n                      <jats:italic>D<\/jats:italic>\n                      surface vs. PINT 0.18\u20130.96, all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      ). In SSD versus HC comparisons, we observed robust patterns of dysconnectivity that were strengthened using a surface\u2010based approach and PINT (Number of differing pairwise\u2010correlations: volume: 404, surface: 570, PINT: 628, FDR corrected).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surface\u2010based and individualized approaches can more sensitively delineate cortical network dysconnectivity differences in people with SSDs. These robust patterns of dysconnectivity were visibly organized in accordance with the cortical hierarchy, as predicted by computational models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hbm.26453","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:26:49Z","timestamp":1692685609000},"page":"5153-5166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Robust hierarchically organized whole\u2010brain patterns of dysconnectivity in schizophrenia spectrum disorders observed after personalized intrinsic network topography"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3028-9864","authenticated-orcid":false,"given":"Erin W.","family":"Dickie","sequence":"first","affiliation":[{"name":"Center for Addiction and Mental Health Campbell Family Mental Health Research  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Shahab","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Hawco","sequence":"additional","affiliation":[{"name":"Center for Addiction and Mental Health Campbell Family Mental Health Research  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayton","family":"Miranda","sequence":"additional","affiliation":[{"name":"Center for Addiction and Mental Health Campbell Family Mental Health Research  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Herman","sequence":"additional","affiliation":[{"name":"Center for Addiction and Mental Health Campbell Family Mental Health Research  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miklos","family":"Argyelan","sequence":"additional","affiliation":[{"name":"Psychiatry Research, The Zucker Hillside Hospital  Glen Cove New York USA"},{"name":"Institute of Behavioral Science, Feinstein Institutes for Medical Research  Manhasset New York USA"},{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie Lisa","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrold","family":"Jeyachandra","sequence":"additional","affiliation":[{"name":"Center for Addiction and Mental Health Campbell Family Mental Health Research  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Anticevic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Psychiatry Research, The Zucker Hillside Hospital  Glen Cove New York USA"},{"name":"Institute of Behavioral Science, Feinstein Institutes for Medical Research  Manhasset New York USA"},{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotle N.","family":"Voineskos","sequence":"additional","affiliation":[{"name":"Center for Addiction and Mental Health Campbell Family Mental Health Research  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-017-9338-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.02.052"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0566"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0059-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32992"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.18040429"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00339.2011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06350-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0101"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.04.009"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00270.2012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0065-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801582115"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.0391"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.02.1174"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.04.078"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa016"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx034"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.194"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.03.012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184661"},{"key":"e_1_2_9_26_1","unstructured":"Esteban O. Blair R. Markiewicz C. J. Berleant S. L. Moodie C. Ma F. Isik A. I. Erramuzpe A. Kent J. D. Goncalves M. DuPre E. Sitek K. R. Gomez D. E. P. Lurie D. J. Ye Z. Salo T. Valabregue R. Amlien I. K. Liem F. \u2026Gorgolewski K. J.(2019).poldracklab\/fmriprep: 1.3.0.post2.https:\/\/doi.org\/10.5281\/zenodo.2565292"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0235-4"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.090"},{"issue":"2","key":"e_1_2_9_29_1","first-page":"89","article-title":"Schizophrenia: A disconnection syndrome?","volume":"3","author":"Friston K. J.","year":"1995","journal-title":"Clinical Neuroscience"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2022.07.012"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.08.005"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4361"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/17.5.461"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.011"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2011.00013"},{"key":"e_1_2_9_37_1","unstructured":"Gorgolewski K. J. Esteban O. Ellis D. G. Notter M. P. Ziegler E. Johnson H. Hamalainen C. Yvernault B. Burns C. Manh\u00e3es\u2010Savio A. Jarecka D. Markiewicz C. J. Salo T. Clark D. Waskom M. Wong J. Modat M. Dewey B. E. Clark M. G. \u2026Ghosh S.(2017).Nipype: a flexible lightweight and extensible neuroimaging data processing framework in Python. 0.13.1.https:\/\/doi.org\/10.5281\/zenodo.581704"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.06.060"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3919"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat9223"},{"key":"e_1_2_9_41_1","unstructured":"Huntenburg J. M.(2014).Evaluating nonlinear coregistration of BOLD EPI and T1w images. Freie Universit\u00e4t Berlin.https:\/\/pure.mpg.de\/pubman\/faces\/ViewItemOverviewPage.jsp?itemId=item_2327525"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0408-6"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy306"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.10.006"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2019.05.017"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy123"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0793-8"},{"key":"e_1_2_9_49_1","first-page":"482","article-title":"Dysconnectivity of multiple brain networks in schizophrenia: A meta\u2010analysis of resting\u2010state functional connectivity","volume":"10","author":"Li S.","year":"2019","journal-title":"Frontiers in Psychiatry\/Frontiers Research Foundation"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2018.07.004"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa088"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.01.022"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.084384"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.12.073"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.11.004"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.110"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.048"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.01.005"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03462-y"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.05.069"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1734"},{"key":"e_1_2_9_62_1","article-title":"Local\u2010global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI","volume":"28","author":"Schaefer, A., Kong, R., Gordon, E. M., Laumann, T. O., Zuo, X.\u2010N., Holmes, A. J., Eickhoff, S. B., & Yeo, B. T. T.","year":"2017","journal-title":"Cerebral Cortex"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa155"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152472"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby166"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2046908"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.03.013"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4164"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0276-1"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2015.00045"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.09.034"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2017.00017"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809141106"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12010056"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24241"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.26453","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:55:23Z","timestamp":1781261723000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.26453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,22]]},"references-count":75,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,10,15]]}},"alternative-id":["10.1002\/hbm.26453"],"URL":"https:\/\/doi.org\/10.1002\/hbm.26453","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.12.13.520333","asserted-by":"object"}]},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,22]]},"assertion":[{"value":"2023-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}