{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:03:39Z","timestamp":1781262219912,"version":"3.54.1"},"reference-count":67,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Increasing evidence has shown a higher sensitivity of Alzheimer's disease (AD) progression by local hippocampal atrophy rather than the whole volume. However, existing morphological methods based on subfield\u2010volume or surface in imaging studies are not capable to describe the comprehensive process of hippocampal atrophy as sensitive as histological findings. To map histological distinctive measurements onto medical magnetic resonance (MR) images, we propose a multiscale skeletal representation (m\u2010s\u2010rep) to quantify focal hippocampal atrophy during AD progression in longitudinal cohorts from the Alzheimer's Disease Neuroimaging Initiative (ADNI). The m\u2010s\u2010rep captures large\u2010to\u2010small\u2010scale hippocampal morphology by spoke interpolation over label projection on skeletal models. To enhance morphological correspondence within subjects, we align the longitudinal m\u2010s\u2010reps by surface\u2010based transformations from baseline to subsequent timepoints. Cross\u2010sectional and longitudinal measurements derived from m\u2010s\u2010rep are statistically analyzed to comprehensively evaluate the bilateral hippocampal atrophy. Our findings reveal that during the early AD progression, atrophy primarily affects the lateral\u2010medial extent of the hippocampus, with a difference of 1.8\u2009mm in lateral\u2010medial width in 2\u2009years preceding conversion (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001), and the medial head exhibits a maximum difference of 3.05%\/year in local atrophy rate (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.011) compared to controls. Moreover, progressive mild cognitive impairment (pMCI) exhibits more severe and widespread atrophy in the head and body compared to stable mild cognitive impairment (sMCI), with a maximum difference of 1.21\u2009mm in thickness in the medial head 1\u2009year preceding conversion (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.012). In summary, our proposed method can quantitatively measure the hippocampal morphological changes on 3T MR images, potentially assisting the pre\u2010diagnosis and prognosis of AD.\n                  <\/jats:p>","DOI":"10.1002\/hbm.26460","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T02:02:37Z","timestamp":1692756157000},"page":"5180-5197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>MR<\/scp>\n                    \u2010based spatiotemporal anisotropic atrophy evaluation of hippocampus in\n                    <scp>Alzheimer's disease<\/scp>\n                    progression by multiscale skeletal representation"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-9777","authenticated-orcid":false,"given":"Na","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Electronic &amp; Information Engineering Harbin Institute of Technology (Shenzhen)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of North Carolina at  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuesheng","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Electronic &amp; Information Engineering Harbin Institute of Technology (Shenzhen)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hantao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Electronic &amp; Information Engineering Harbin Institute of Technology (Shenzhen)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfei","family":"Ye","sequence":"additional","affiliation":[{"name":"International Research Institute for Artificial Intelligence Harbin Institute of Technology at Shenzhen  Shenzhen China"},{"name":"Peng Cheng Laboratory  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"},{"name":"Key Lab of Medical Engineering for Cardiovascular Disease Ministry of Education  Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8819-6228","authenticated-orcid":false,"given":"Ting","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Electronic &amp; Information Engineering Harbin Institute of Technology (Shenzhen)  Shenzhen China"},{"name":"International Research Institute for Artificial Intelligence Harbin Institute of Technology at Shenzhen  Shenzhen China"},{"name":"Peng Cheng Laboratory  Shenzhen China"},{"name":"Guangdong Provincial Key Laboratory of Aerospace Communication and Networking Technology Harbin Institute of Technology (Shenzhen)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801093115"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013699998"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2020.2964499"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050622"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004973"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116984"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102305"},{"key":"e_1_2_10_11_1","article-title":"Medial temporal lobe subregional atrophy in aging and Alzheimer's disease: A longitudinal study. 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