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It evaluates global changes in the frequency of resting\u2010state brain activity, which are associated with cognitive status. However, it remains unclear what neural mechanism causes the frequency changes. To understand this, it is important to identify cortical regions that mainly contribute to these changes. We retrospectively analysed the clinical records from 310 individuals with cognitive impairment who visited the outpatient department at our hospital. The analysis included resting\u2010state magnetoencephalography, neuropsychological assessment, and clinical diagnosis data. Regional oscillatory intensities were estimated from the magnetoencephalography data, which were statistically analysed, along with neuropsychological assessment scores, and the severity of cognitive impairment associated with clinical diagnosis. The regional oscillatory intensity covering a wide range of regions and frequencies was significantly associated with neuropsychological assessment scores and differed between healthy individuals and patients with cognitive impairment. However, these associations and differences in all conditions were overlapped by a single change in beta frequency in the left supramarginal gyrus. High frequency oscillatory intensity in the left supramarginal gyrus is associated with cognitive impairment levels among patients who were concerned about dementia. It provides new insights into cognitive status measurements using magnetoencephalography, which is expected to develop as an objective index to be used alongside traditional neuropsychological assessments.<\/jats:p>","DOI":"10.1002\/hbm.26507","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T14:52:36Z","timestamp":1696431156000},"page":"6214-6226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Decreased beta\u2010band activity in left supramarginal gyrus reflects cognitive decline: Evidence from a large clinical dataset in patients with dementia"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5820-5899","authenticated-orcid":false,"given":"Hideyuki","family":"Hoshi","sequence":"first","affiliation":[{"name":"Precision Medicine Centre Hokuto Hospital  Obihiro City Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1398-0696","authenticated-orcid":false,"given":"Momoko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Precision Medicine Centre Kumagaya General Hospital  Kumagaya City Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-3881","authenticated-orcid":false,"given":"Yoko","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kumagaya General Hospital  Kumagaya City Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2275-9598","authenticated-orcid":false,"given":"Keisuke","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Kumagaya General Hospital  Kumagaya City Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0225-3637","authenticated-orcid":false,"given":"Sayuri","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Kumagaya General Hospital  Kumagaya City Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-110X","authenticated-orcid":false,"given":"Yoshihito","family":"Shigihara","sequence":"additional","affiliation":[{"name":"Precision Medicine Centre Hokuto Hospital  Obihiro City Hokkaido Japan"},{"name":"Precision Medicine Centre Kumagaya General Hospital  Kumagaya City Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/906038"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12068"},{"key":"e_1_2_12_4_1","volume-title":"SPM12 Manual","author":"Ashburner J.","year":"2014"},{"key":"e_1_2_12_5_1","first-page":"245","article-title":"A cognitive bedside assessment beyond the MMSE: The Addenbrooke's cognitive examination","volume":"7","author":"Bak T. 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