{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:11Z","timestamp":1786977851125,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Chinese Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2021ZD0203800"],"award-info":[{"award-number":["2021ZD0203800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Chinese Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2012CB825500"],"award-info":[{"award-number":["2012CB825500"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Chinese Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2015CB351701"],"award-info":[{"award-number":["2015CB351701"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871104"],"award-info":[{"award-number":["31871104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571112"],"award-info":[{"award-number":["31571112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31830037"],"award-info":[{"award-number":["31830037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amblyopia is a developmental visual disorder that causes substantial visual deficits. Studies using resting\u2010state functional magnetic resonance imaging have disclosed abnormal brain functional connectivity (FC) both across long\u2010range cortical sites and within the visual cortex in amblyopes, which is considered to be related to impaired visual functions. However, little work has examined whether restoring the vision of amblyopes accompanies with an improvement of FC. Here in adult amblyopes and healthy participants, we compared their brain FC before and after an altered\u2010reality adaptation training. Before the training, the voxel\u2010wise FCs of amblyopia patients were substantially weaker than those of healthy control participants both within and across the early visual areas. After the training, visual acuities improved in amblyopes but not in the control participants. The effect kept strengthening in the subsequent month without further adaptation. Importantly, we observed enhanced voxel\u2010wise FC both within and across the early visual areas of amblyopes. Moreover, the enhancement continued for at least 1 month. These results suggest that the effective treatment can improve both the amblyopes' vision and functional connections in the visual cortex.<\/jats:p>","DOI":"10.1002\/hbm.26526","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T06:31:04Z","timestamp":1699252264000},"page":"6499-6510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treating amblyopia using altered reality enhances the fine\u2010scale functional correlations in early visual areas"],"prefix":"10.1002","volume":"44","author":[{"given":"Xue","family":"Dong","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Behavioral Science, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Du","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Behavioral Science, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-8454","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6009-7903","authenticated-orcid":false,"given":"Zhihao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Psychology Shenzhen University  Shenzhen Guangdong China"},{"name":"Department of Psychiatry and Behavioral Sciences Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-9663","authenticated-orcid":false,"given":"Min","family":"Bao","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Behavioral Science, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"issue":"267","key":"e_1_2_8_2_1","first-page":"1","article-title":"MEG and EEG data analysis with MNE\u2010Python","volume":"7","author":"Alexandre G.","year":"2013","journal-title":"Frontiers in Neuroscience"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpa.2002.124902"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797617728126"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721419862290"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/18.13.23"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2012.11.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2023.101168"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2006.07.008"},{"issue":"3","key":"e_1_2_8_11_1","first-page":"467","article-title":"Contrast sensitivity in anisometropic amblyopia","volume":"21","author":"Bradley A.","year":"1981","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0363-13.2013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2015.01.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2007.01.119"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/13.2.14"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/612086"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14969"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3055-10.2010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.2.181"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120373"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.4.1907"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.00583"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68581-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/11.6.4"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523817000207"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2014.00062"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1167\/16.3.18"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19809-w"},{"key":"e_1_2_8_29_1","unstructured":"Kleiner M. Brainard D. &Pelli D.(2007).What's new in Psychtoolbox\u20103?"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.06.026"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00720-7"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2020.07.014"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2015.01.002"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7233"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-017-1824-0"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043373"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-019-0145-2"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.04.021"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2008.09.002"},{"issue":"12","key":"e_1_2_8_40_1","first-page":"745","article-title":"Amblyopia: Detection and treatment","volume":"100","author":"McConaghy J. R.","year":"2019","journal-title":"American Family Physician"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.01.022"},{"issue":"1","key":"e_1_2_8_42_1","first-page":"31","article-title":"Human amblyopia: Consequence of chronic interocular suppression","volume":"1","author":"Sireteanu R.","year":"1982","journal-title":"Human Neurobiology"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(81)90010-9"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1604"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800007793"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00088"},{"key":"e_1_2_8_48_1","volume-title":"Paper presented at the medical imaging 2014: Biomedical applications in molecular, structural, and functional imaging","author":"Wang J.","year":"2014"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6158-09.2010"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303778"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T21:02:31Z","timestamp":1702414951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.26526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,6]]},"references-count":49,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2023,12,15]]}},"alternative-id":["10.1002\/hbm.26526"],"URL":"https:\/\/doi.org\/10.1002\/hbm.26526","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,6]]},"assertion":[{"value":"2023-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}