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Because of the motor symptom, idiopathic generalized epilepsy (IGE) patients with generalized tonic\u2013clonic seizure have been recognized to associate with motor abnormalities, but the functional interaction in the cerebello\u2013cerebral circuit is still poorly understood. Resting\u2010state functional magnetic resonance imaging data were collected for 101 IGE patients and 106 healthy controls. The voxel\u2010based functional connectivity (FC) between cerebral cortex and the cerebellum was contacted. The functional gradient and independent components analysis were applied to evaluate cerebello\u2013cerebral functional integration on the voxel\u2010based FC. Cerebellar motor components were further linked to cerebellar gradient. Results revealed cerebellar motor functional modules were closely related to cerebral motor components. The altered mapping of cerebral motor components to cerebellum was observed in motor module in patients with IGE. In addition, patients also showed compression in cerebello\u2013cerebral functional gradient between motor and cognition modules. Interestingly, the contribution of the motor components to the gradient was unbalanced between bilateral primary sensorimotor components in patients: the increase was observed in cerebellar cognitive module for the dominant hemisphere primary sensorimotor, but the decrease was found in the cerebellar cognitive module for the nondominant hemisphere primary sensorimotor. The present findings suggest that the cerebral primary motor system affects the hierarchical architecture of cerebellum, and substantially contributes to the functional integration evidence to understand the motor functional abnormality in IGE patients.<\/jats:p>","DOI":"10.1002\/hbm.26551","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T15:22:52Z","timestamp":1702048972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The role of the primary sensorimotor system in generalized epilepsy: Evidence from the cerebello\u2013cerebral functional integration"],"prefix":"10.1002","volume":"45","author":[{"given":"Junxia","family":"Chen","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu P. R. 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