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This computation, however, is greatly complicated by the observer's movements, which generate a global pattern of motion on the observer's retina. How the visual system implements this computation is poorly understood. Since we are potentially able to detect a moving object if its motion differs in velocity (or direction) from the expected optic flow generated by our own motion, here we manipulated the relative motion velocity between the observer and the object within a stationary scene as a strategy to test how the brain accomplishes object\u2010motion detection. Specifically, we tested the neural sensitivity of brain regions that are known to respond to egomotion\u2010compatible visual motion (i.e., egomotion areas: cingulate sulcus visual area, posterior cingulate sulcus area, posterior insular cortex [PIC], V6+, V3A, IPSmot\/VIP, and MT+) to a combination of different velocities of visually induced translational self\u2010 and object\u2010motion within a virtual scene while participants were instructed to detect object\u2010motion. To this aim, we combined individual surface\u2010based brain mapping, task\u2010evoked activity by functional magnetic resonance imaging, and parametric and representational similarity analyses. We found that all the egomotion regions (except area PIC) responded to all the possible combinations of self\u2010 and object\u2010motion and were modulated by the self\u2010motion velocity. Interestingly, we found that, among all the egomotion areas, only MT+, V6+, and V3A were further modulated by object\u2010motion velocities, hence reflecting their possible role in discriminating between distinct velocities of self\u2010 and object\u2010motion. We suggest that these egomotion regions may be involved in the complex computation required for detecting scene\u2010relative object\u2010motion during self\u2010motion.<\/jats:p>","DOI":"10.1002\/hbm.26571","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T12:05:04Z","timestamp":1705061104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neural sensitivity to translational self\u2010 and object\u2010motion velocities"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7000-550X","authenticated-orcid":false,"given":"Valentina","family":"Sulpizio","sequence":"first","affiliation":[{"name":"Department of Cognitive and Motor Rehabilitation and Neuroimaging Santa Lucia Foundation (IRCCS Fondazione Santa Lucia)  Rome Italy"},{"name":"Department of Psychology Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"von Gal","sequence":"additional","affiliation":[{"name":"Department of Psychology Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-4247","authenticated-orcid":false,"given":"Gaspare","family":"Galati","sequence":"additional","affiliation":[{"name":"Department of Cognitive and Motor Rehabilitation and Neuroimaging Santa Lucia Foundation (IRCCS Fondazione Santa Lucia)  Rome Italy"},{"name":"Department of Psychology Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Fattori","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Galletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4445-0391","authenticated-orcid":false,"given":"Sabrina","family":"Pitzalis","sequence":"additional","affiliation":[{"name":"Department of Cognitive and Motor Rehabilitation and Neuroimaging Santa Lucia Foundation (IRCCS Fondazione Santa Lucia)  Rome Italy"},{"name":"Department of Movement, Human and Health Sciences University of Rome \u201cForo Italico\u201d  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523808080024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/266585"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102984108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm107"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02207.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(01)00198-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207457309147657"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-012-3159-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp268"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01120.2010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0395-11.2011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4522-12.2013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.3.902"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1492(199706\/08)10:4\/5<171::AID-NBM453>3.0.CO;2-L"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2020.12.021"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118581"},{"key":"e_1_2_9_19_1","unstructured":"Diedrichsen J. 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