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Proximity to the vertebral column and lungs results in strong spatial inhomogeneity and temporal fluctuations in B\n                      <jats:sub>0<\/jats:sub>\n                      . Increasing field strength enables higher spatial resolution and improved sensitivity to blood oxygenation level\u2010dependent (BOLD) signal, but amplifies the effects of B\n                      <jats:sub>0<\/jats:sub>\n                      inhomogeneity. In this work, we present the first task fMRI in the spinal cord at 7\u2009T. Further, we compare the performance of single\u2010shot and multi\u2010shot 2D echo\u2010planar imaging (EPI) protocols, which differ in sensitivity to spatial and temporal B\n                      <jats:sub>0<\/jats:sub>\n                      inhomogeneity. The cervical spinal cords of 11 healthy volunteers were scanned at 7\u2009T using single\u2010shot 2D EPI at 0.75\u2009mm in\u2010plane resolution and multi\u2010shot 2D EPI at 0.75 and 0.6\u2009mm in\u2010plane resolutions. All protocols used 3\u2009mm slice thickness. For each protocol, the BOLD response to 13 10\u2010s noxious thermal stimuli applied to the right thumb was acquired in a 10\u2010min fMRI run. Image quality, temporal signal to noise ratio (SNR), and BOLD activation (percent signal change and\n                      <jats:italic>z<\/jats:italic>\n                      \u2010stat) at both individual\u2010 and group\u2010level were evaluated between the protocols. Temporal SNR was highest in single\u2010shot and multi\u2010shot 0.75\u2009mm protocols. In group\u2010level analyses, activation clusters appeared in all protocols in the ipsilateral dorsal quadrant at the expected C6 neurological level. In individual\u2010level analyses, activation clusters at the expected level were detected in some, but not all subjects and protocols. Single\u2010shot 0.75\u2009mm generally produced the highest mean\n                      <jats:italic>z<\/jats:italic>\n                      \u2010statistic, while multi\u2010shot 0.60\u2009mm produced the best\u2010localized activation clusters and the least geometric distortion. Larger than expected within\u2010subject segmental variation of BOLD activation along the cord was observed. Group\u2010level sensory task fMRI of the cervical spinal cord is feasible at 7\u2009T with single\u2010shot or multi\u2010shot EPI. The best choice of protocol will likely depend on the relative importance of sensitivity to activation versus spatial localization of activation for a given experiment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practitioner Points<\/jats:title>\n                    <jats:p>\n                      <jats:list>\n                        <jats:list-item>\n                          <jats:p>First stimulus task fMRI results in the spinal cord at 7\u2009T.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Single\u2010shot 0.75\u2009mm 2D EPI produced the highest mean\n                            <jats:italic>z<\/jats:italic>\n                            \u2010statistic.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Multi\u2010shot 0.60\u2009mm 2D EPI provided the best\u2010localized activation and least distortion.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hbm.26597","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T07:05:36Z","timestamp":1708412736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Thermal stimulus task\n                    <scp>fMRI<\/scp>\n                    in the cervical spinal cord at 7\u2009Tesla"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7877-4813","authenticated-orcid":false,"given":"Alan C.","family":"Seifert","sequence":"first","affiliation":[{"name":"Biomedical Engineering and Imaging Institute Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Diagnostic, Molecular, and Interventional Radiology Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Graduate School of Biomedical Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Psychiatry Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-4723","authenticated-orcid":false,"given":"Yazhuo","family":"Kong","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"},{"name":"Institute of Psychology Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3986-1719","authenticated-orcid":false,"given":"Falk","family":"Eippert","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"},{"name":"Max Planck Research Group Pain Perception Max Planck Institute for Human Cognitive and Brain Sciences  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Tracey","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Johanna","family":"Vannesjo","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"},{"name":"Department of Physics Norwegian University of Science and Technology (NTNU)  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1854","article-title":"Functional MR imaging of the cervical spinal cord by use of median nerve stimulation and fist clenching","volume":"22","author":"Backes W. H.","year":"2001","journal-title":"AJNR. 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