{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:36:14Z","timestamp":1784957774902,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009607","name":"McDonnell Center for Systems Neuroscience","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000135","name":"NIH Blueprint for Neuroscience Research","doi-asserted-by":"publisher","award":["R01 DC013803"],"award-info":[{"award-number":["R01 DC013803"]}],"id":[{"id":"10.13039\/100000135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000135","name":"NIH Blueprint for Neuroscience Research","doi-asserted-by":"publisher","award":["R01 NS120954"],"award-info":[{"award-number":["R01 NS120954"]}],"id":[{"id":"10.13039\/100000135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000135","name":"NIH Blueprint for Neuroscience Research","doi-asserted-by":"publisher","award":["R56 MH113634"],"award-info":[{"award-number":["R56 MH113634"]}],"id":[{"id":"10.13039\/100000135","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2024,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The frontal aslant tract (FAT) is a crucial neural pathway of language and speech, but little is known about its connectivity and segmentation differences across populations. In this study, we investigate the probabilistic coverage of the FAT in a large sample of 1065 young adults. Our primary goal was to reveal individual variability and lateralization of FAT and its structure\u2013function correlations in language processing. The study utilized diffusion MRI data from 1065 subjects obtained from the Human Connectome Project. Automated tractography using DSI Studio software was employed to map white matter bundles, and the results were examined to study the population variation of the FAT. Additionally, anatomical dissections were performed to validate the fiber tracking results. The tract\u2010to\u2010region connectome, based on Human Connectome Project\u2010MMP parcellations, was utilized to provide population probability of the tract\u2010to\u2010region connections. Our results showed that the left anterior FAT exhibited the most substantial individual differences, particularly in the superior and middle frontal gyrus, with greater variability in the superior than the inferior region. Furthermore, we found left lateralization in FAT, with a greater difference in coverage in the inferior and posterior portions. Additionally, our analysis revealed a significant positive correlation between the left FAT inferior coverage area and the performance on the oral reading recognition (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.016) and picture vocabulary (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0026) tests. In comparison, fractional anisotropy of the right FAT exhibited marginal significance in its correlation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.056) with Picture Vocabulary Test. Our findings, combined with the connectivity patterns of the FAT, allowed us to segment its structure into anterior and posterior segments. We found significant variability in FAT coverage among individuals, with left lateralization observed in both macroscopic shape measures and microscopic diffusion metrics. Our findings also suggested a potential link between the size of the left FAT's inferior coverage area and language function tests. These results enhance our understanding of the FAT's role in brain connectivity and its potential implications for language and executive functions.\n                  <\/jats:p>","DOI":"10.1002\/hbm.26630","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T08:45:15Z","timestamp":1708418715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Probabilistic coverage of the frontal aslant tract in young adults: Insights into individual variability, lateralization, and language functions"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5312-6029","authenticated-orcid":false,"given":"Wen\u2010Jieh","family":"Linn","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh  Pittsburgh Pennsylvania 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Hospital El Cruce  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury","family":"Anania","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Fernandez\u2010Miranda","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Cheng","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of 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