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To address the complexity of the role of the thalamic nuclei in psychosis, we introduced micro\u2010co\u2010activation patterns (\u03bcCAPs) and employed this method on the human genetic model of schizophrenia 22q11.2 deletion syndrome (22q11.2DS). Participants underwent resting\u2010state functional MRI and a data\u2010driven iterative process resulting in the identification of six whole\u2010brain \u03bcCAPs with specific activity patterns within the thalamus. Unlike conventional methods, \u03bcCAPs extract dynamic spatial patterns that reveal partially overlapping and non\u2010mutually exclusive functional subparts. Thus, the \u03bcCAPs method detects finer foci of activity within the initial seed region, retaining valuable and clinically relevant temporal and spatial information. We found that a \u03bcCAP showing co\u2010activation of the mediodorsal thalamus with brain\u2010wide cortical regions was expressed significantly less frequently in patients with 22q11.2DS, and its occurrence negatively correlated with the severity of positive psychotic symptoms. Additionally, activity within the auditory\u2013visual cortex and their respective geniculate nuclei was expressed in two different \u03bcCAPs. One of these auditory\u2013visual \u03bcCAPs co\u2010activated with salience areas, while the other co\u2010activated with the default mode network (DMN). A significant shift of occurrence from the salience+visuo\u2010auditory\u2010thalamus to the DMN\u2009+\u2009visuo\u2010auditory\u2010thalamus \u03bcCAP was observed in patients with 22q11.2DS. Thus, our findings support existing research on the gatekeeping role of the thalamus for sensory information in the pathophysiology of psychosis and revisit the evidence of geniculate nuclei hyperconnectivity with the audio\u2010visual cortex in 22q11.2DS in the context of dynamic functional connectivity, seen here as the specific hyper\u2010occurrence of these circuits with the task\u2010negative brain networks.<\/jats:p>","DOI":"10.1002\/hbm.26649","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T10:05:30Z","timestamp":1711188330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Thalamic contributions to psychosis susceptibility: Evidence from co\u2010activation patterns accounting for intra\u2010seed spatial variability (\n                    <scp>\u03bcCAPs<\/scp>\n                    )"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2990-4372","authenticated-orcid":false,"given":"Farnaz","family":"Delavari","sequence":"first","affiliation":[{"name":"Developmental Imaging and Psychopathology Laboratory University of Geneva School of Medicine Geneva Switzerland"},{"name":"Neuro\u2010X Institute \u00c9cole Polytechnique F\u00c9d\u00c9rale de Lausanne Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Sandini","sequence":"additional","affiliation":[{"name":"Developmental Imaging and Psychopathology Laboratory University of Geneva School of Medicine Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Kojovic","sequence":"additional","affiliation":[{"name":"Autism Brain and Behavior Lab, Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi F.","family":"Saccaro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Psychiatry Department University of Geneva Geneva Switzerland"},{"name":"Psychiatry Department Geneva University Hospital Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Eliez","sequence":"additional","affiliation":[{"name":"Developmental Imaging and Psychopathology Laboratory University of Geneva School of Medicine Geneva Switzerland"},{"name":"Department of Genetic Medicine and Development University of Geneva School of Medicine Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Van De Ville","sequence":"additional","affiliation":[{"name":"Neuro\u2010X Institute \u00c9cole Polytechnique F\u00c9d\u00c9rale de Lausanne Geneva Switzerland"},{"name":"Department of Radiology and Medical Informatics University of Geneva (UNIGE) Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-4031","authenticated-orcid":false,"given":"Thomas A. 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