{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:24:19Z","timestamp":1789986259448,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160930"],"award-info":[{"award-number":["82160930"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gray matter (GM) atrophy and white matter (WM) lesions may contribute to cognitive decline in patients with delayed neurological sequelae (DNS) after carbon monoxide (CO) poisoning. However, there is currently a lack of evidence supporting this relationship. This study aimed to investigate the volume of GM, cortical thickness, and burden of WM lesions in 33 DNS patients with dementia, 24 DNS patients with mild cognitive impairment, and 51 healthy controls. Various methods, including voxel\u2010based, deformation\u2010based, surface\u2010based, and atlas\u2010based analyses, were used to examine GM structures. Furthermore, we explored the connection between GM volume changes, WM lesions burden, and cognitive decline. Compared to the healthy controls, both patient groups exhibited widespread GM atrophy in the cerebral cortices (for volume and cortical thickness), subcortical nuclei (for volume), and cerebellum (for volume) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05 corrected for false discovery rate [FDR]). The total volume of GM atrophy in 31 subregions, which included the default mode network (DMN), visual network (VN), and cerebellar network (CN) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05, FDR\u2010corrected), independently contributed to the severity of cognitive impairment (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). Additionally, WM lesions impacted cognitive decline through both direct and indirect effects, with the latter mediated by volume reduction in 16 subregions of cognitive networks (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). These preliminary findings suggested that both GM atrophy and WM lesions were involved in cognitive decline in DNS patients following CO poisoning. Moreover, the reduction in the volume of DMN, VN, and posterior CN nodes mediated the WM lesions\u2010induced cognitive decline.\n                  <\/jats:p>","DOI":"10.1002\/hbm.26656","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T09:39:36Z","timestamp":1711445976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gray matter atrophy and white matter lesions burden in delayed cognitive decline following carbon monoxide poisoning"],"prefix":"10.1002","volume":"45","author":[{"given":"Yanli","family":"Zhang","sequence":"first","affiliation":[{"name":"Deparment of Radiology The First Hospital of Lanzhou University  Lanzhou Gansu China"},{"name":"Radiological Clinical Medicine Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"The Intelligent Imaging Medical Engineering Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"Accurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu Province  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Hospital of Lanzhou University  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6340-2232","authenticated-orcid":false,"given":"Shuaiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Deparment of Radiology The First Hospital of Lanzhou University  Lanzhou Gansu China"},{"name":"Radiological Clinical Medicine Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"The Intelligent Imaging Medical Engineering Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"Accurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu Province  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Deparment of Radiology The First Hospital of Lanzhou University  Lanzhou Gansu China"},{"name":"Radiological Clinical Medicine Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"The Intelligent Imaging Medical Engineering Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"Accurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu Province  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Li","sequence":"additional","affiliation":[{"name":"Deparment of Radiology The First Hospital of Lanzhou University  Lanzhou Gansu China"},{"name":"Radiological Clinical Medicine Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"The Intelligent Imaging Medical Engineering Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"Accurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu Province  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunlin","family":"Guo","sequence":"additional","affiliation":[{"name":"Deparment of Radiology The First Hospital of Lanzhou University  Lanzhou Gansu China"},{"name":"Radiological Clinical Medicine Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"The Intelligent Imaging Medical Engineering Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"Accurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu Province  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-1922","authenticated-orcid":false,"given":"Junqiang","family":"Lei","sequence":"additional","affiliation":[{"name":"Deparment of Radiology The First Hospital of Lanzhou University  Lanzhou Gansu China"},{"name":"Radiological Clinical Medicine Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"The Intelligent Imaging Medical Engineering Research Center of Gansu Province  Lanzhou Gansu China"},{"name":"Accurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu Province  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz337"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3489"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00187"},{"issue":"1","key":"e_1_2_9_5_1","first-page":"23","article-title":"Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning","volume":"37","author":"Chang D. 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