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A more nuanced understanding of the amygdala's role in emotion processing, particularly relating to fear, is needed given the importance of effective emotional functioning for everyday function and mental health. We studied 86 healthy participants (44 females), aged 18\u201349 (mean 26.12\u2009\u00b1\u20096.6) years, who underwent multiband functional magnetic resonance imaging. We specifically examined the reactivity of four amygdala subregions (using regions of interest analysis) and related brain connectivity networks (using generalized psycho\u2010physiological interaction) to fear, angry, and happy facial stimuli using an emotional face\u2010matching task. All amygdala subregions responded to all stimuli (<jats:italic>p<\/jats:italic>\u2010FDR\u2009&lt;\u2009.05), with this reactivity strongly driven by the superficial and centromedial amygdala (<jats:italic>p<\/jats:italic>\u2010FDR\u2009&lt;\u2009.001). Yet amygdala subregions selectively showed strong functional connectivity with other occipitotemporal and inferior frontal brain regions with particular sensitivity to fear recognition and strongly driven by the basolateral amygdala (<jats:italic>p<\/jats:italic>\u2010FDR\u2009&lt;\u2009.05). These findings suggest that amygdala specialization to fear may not be reflected in its local activity but in its connectivity with other brain regions within a specific face\u2010processing network.<\/jats:p>","DOI":"10.1002\/hbm.26673","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T07:28:46Z","timestamp":1712647726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Specialization of amygdala subregions in emotion processing"],"prefix":"10.1002","volume":"45","author":[{"given":"Izelle","family":"Labuschagne","sequence":"first","affiliation":[{"name":"Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences Australian Catholic University  Melbourne Victoria Australia"},{"name":"School of Psychology The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Dominguez","sequence":"additional","affiliation":[{"name":"School of Psychology Deakin University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-1292","authenticated-orcid":false,"given":"Sally","family":"Grace","sequence":"additional","affiliation":[{"name":"Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences Australian Catholic University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3346-566X","authenticated-orcid":false,"given":"Simone","family":"Mizzi","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Science RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie D.","family":"Henry","sequence":"additional","affiliation":[{"name":"School of Psychology The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Rabinak","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences Australian Catholic University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Lorenzetti","sequence":"additional","affiliation":[{"name":"Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences Australian Catholic University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Terrett","sequence":"additional","affiliation":[{"name":"Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences Australian Catholic University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Rendell","sequence":"additional","affiliation":[{"name":"Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences Australian Catholic University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangor","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Auckland University of Technology  Auckland New Zealand"},{"name":"The Florey Institute of Neuroscience and Mental Health The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren R.","family":"Hocking","sequence":"additional","affiliation":[{"name":"Institute for Health &amp; Sport Victoria University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Heinrichs","sequence":"additional","affiliation":[{"name":"Department of Psychology Albert\u2010Ludwigs\u2010University of Freiburg  Freiburg im Breisgau Germany"},{"name":"Freiburg Brain Imaging Center University Medical Center, Albert\u2010Ludwigs University of Freiburg  Freiburg im Breisgau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.06.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00336-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2744-10.2011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(97)00166-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.05.001"},{"key":"e_1_2_8_9_1","unstructured":"Brett M. 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