{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:35:26Z","timestamp":1791236126638,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF21OC0072828"],"award-info":[{"award-number":["NNF21OC0072828"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF121"],"award-info":[{"award-number":["DNRF121"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Temporal dynamics of local cortical rhythms during acute pain remain largely unknown. The current study used a novel approach based on transcranial magnetic stimulation combined with electroencephalogram (TMS\u2010EEG) to investigate evoked\u2010oscillatory cortical activity during acute pain. Motor (M1) and dorsolateral prefrontal cortex (DLPFC) were probed by TMS, respectively, to record oscillatory power (event\u2010related spectral perturbation and relative spectral power) and phase synchronization (inter\u2010trial coherence) by 63 EEG channels during experimentally induced acute heat pain in 24 healthy participants. TMS\u2010EEG was recorded before, during, and after noxious heat (acute pain condition) and non\u2010noxious warm (Control condition), delivered in a randomized sequence. The main frequency bands (\u03b1, \u03b21, and \u03b22) of TMS\u2010evoked potentials after M1 and DLPFC stimulation were recorded close to the TMS coil and remotely. Cold and heat pain thresholds were measured before TMS\u2010EEG. Over M1, acute pain decreased \u03b1\u2010band oscillatory power locally and \u03b1\u2010band phase synchronization remotely in parietal\u2013occipital clusters compared with non\u2010noxious warm (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). The remote (parietal\u2013occipital) decrease in \u03b1\u2010band phase synchronization during acute pain correlated with the cold (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.001) and heat pain thresholds (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.023) and to local (M1) \u03b1\u2010band oscillatory power decrease (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.024). Over DLPFC, acute pain only decreased \u03b21\u2010band power locally compared with non\u2010noxious warm (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.015). Thus, evoked\u2010oscillatory cortical activity to M1 stimulation is reduced by acute pain in central and parietal\u2013occipital regions and correlated with pain sensitivity, in contrast to DLPFC, which had only local effects. This finding expands the significance of \u03b1 and \u03b2 band oscillations and may have relevance for pain therapies.\n                  <\/jats:p>","DOI":"10.1002\/hbm.26679","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T07:04:53Z","timestamp":1713769493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Evoked oscillatory cortical activity during acute pain: Probing brain in pain by transcranial magnetic stimulation combined with electroencephalogram"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-3723","authenticated-orcid":false,"given":"Enrico","family":"De Martino","sequence":"first","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adenauer","family":"Casali","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Casarotto","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences University of Milan  Milan Italy"},{"name":"IRCCS Fondazione Don Carlo Gnocchi  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1672-4921","authenticated-orcid":false,"given":"Bruno Andry","family":"Couto","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Rosanova","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-4860","authenticated-orcid":false,"given":"Thomas","family":"Graven\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3411-632X","authenticated-orcid":false,"given":"Daniel Ciampi","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of 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