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In this study, we investigated how adults with GTS and healthy controls (HC) learn two types of regularities in a sequence: statistics (non\u2010adjacent probabilities) and rules (predefined order). Participants completed a visuomotor sequence learning task while EEG was recorded. To understand the neurophysiological underpinnings of these regularities in GTS, multivariate pattern analyses on the temporally decomposed EEG signal as well as sLORETA source localisation method were conducted. We found that people with GTS showed superior statistical learning but comparable rule\u2010based learning compared to HC participants. Adults with GTS had different neural representations for both statistics and rules than HC adults; specifically, adults with GTS maintained the regularity representations longer and had more overlap between them than HCs. Moreover, over different time scales, distinct fronto\u2010parietal structures contribute to statistical learning in the GTS and HC groups. We propose that hyper\u2010learning in GTS is a consequence of the altered sensitivity to encode complex statistics, which might lead to habitual actions.<\/jats:p>","DOI":"10.1002\/hbm.26719","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T06:44:35Z","timestamp":1717397075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neural representations of statistical and rule\u2010based predictions in <scp>Gilles de la Tourette<\/scp> syndrome"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6575-727X","authenticated-orcid":false,"given":"Adam","family":"Takacs","sequence":"first","affiliation":[{"name":"Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"University Neuropsychology Center, Faculty of Medicine, Technische Universit\u00e4t 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