{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:02:40Z","timestamp":1781816560095,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2024,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The cerebellum has been involved in social abilities and autism. Given that the cerebellum is connected to the cortex via the cerebello\u2010thalamo\u2010cortical loop, the connectivity between the cerebellum and cortical regions involved in social interactions, that is, the right temporo\u2010parietal junction (rTPJ) has been studied in individuals with autism, who suffer from prototypical deficits in social abilities. However, existing studies with small samples of categorical, case\u2013control comparisons have yielded inconsistent results due to the inherent heterogeneity of autism, suggesting that investigating how clinical dimensions are related to cerebellar\u2013rTPJ functional connectivity might be more relevant. Therefore, our objective was to study the functional connectivity between the cerebellum and rTPJ, focusing on its association with social abilities from a dimensional perspective in a transdiagnostic sample. We analyzed structural magnetic resonance imaging (MRI) and functional MRI (fMRI) scans obtained during naturalistic films watching from a large transdiagnostic dataset, the Healthy Brain Network (HBN), and examined the association between cerebellum\u2013rTPJ functional connectivity and social abilities measured with the social responsiveness scale (SRS). We conducted univariate seed\u2010to\u2010voxel analysis, multivariate canonical correlation analysis (CCA), and predictive support vector regression (SVR). We included 1404 subjects in the structural analysis (age: 10.516\u2009\u00b1\u20093.034, range: 5.822\u201321.820, 506 females) and 414 subjects in the functional analysis (age: 11.260\u2009\u00b1\u20093.318\u2009years, range: 6.020\u201321.820, 161 females). Our CCA model revealed a significant association between cerebellum\u2013rTPJ functional connectivity, full\u2010scale IQ (FSIQ) and SRS scores. However, this effect was primarily driven by FSIQ as suggested by SVR and univariate seed\u2010to\u2010voxel analysis. We also demonstrated the specificity of the rTPJ and the influence of structural anatomy in this association. Our results suggest that there is a complex relationship between cerebellum\u2013rTPJ connectivity, social performance and IQ. This relationship is specific to the cerebellum\u2013rTPJ connectivity, and is largely related to structural anatomy in these two regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Practitioner Points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We analyzed cerebellum\u2013right temporoparietal junction (rTPJ) connectivity in a pediatric transdiagnostic sample.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We found a complex relationship between cerebellum and rTPJ connectivity, social performance and IQ.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cerebellum and rTPJ functional connectivity is related to structural anatomy in these two regions.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/hbm.26749","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T09:18:56Z","timestamp":1720689536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cerebellum and social abilities: A structural and functional connectivity study in a transdiagnostic sample"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3679-4300","authenticated-orcid":false,"given":"Yue","family":"Kong","sequence":"first","affiliation":[{"name":"INSERM U955, Institut Mondor de la Recherche Biom\u00e9dicale (IMRB), Univ. 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Paris East Cr\u00e9teil, Team 15 Translational Neuropsychiatry, DMU IMPACT, Henri Mondor \u2013 AP\u2010HP Paris University Hospitals  Cr\u00e9teil France"},{"name":"NeuroSpin, CEA, Paris\u2010Saclay University, France  Saclay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Neu","sequence":"additional","affiliation":[{"name":"INSERM U955, Institut Mondor de la Recherche Biom\u00e9dicale (IMRB), Univ. 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