{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:04:41Z","timestamp":1761563081136,"version":"3.41.2"},"reference-count":71,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["09150172010044"],"award-info":[{"award-number":["09150172010044"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long\u2010term cognitive impairment is common in cardiac arrest survivors. Screening to identify patients at risk is recommended. Functional magnetic resonance brain imaging (fMRI) holds potential to contribute to prediction of cognitive outcomes. In this study, we investigated the possible value of early changes in resting\u2010state networks for predicting short and long\u2010term cognitive functioning of cardiac arrest survivors. We performed a prospective multicenter cohort study in cardiac arrest survivors in three Dutch hospitals. Resting\u2010state fMRI scans were acquired within a month after cardiac arrest. We primarily focused on functional connectivity within the default\u2010mode network (DMN) and salience network (SN), and additionally explored functional connectivity in seven other networks. Cognitive outcome was measured using the Montreal Cognitive Assessment (MoCA) during hospital admission and at 3 and 12\u2009months, and by neuropsychological examination (NPE) at 12\u2009months. We tested mixed effects models to evaluate the value of connectivity within the networks for predicting global cognitive outcomes at the three time points, and long\u2010term cognitive outcomes in the memory, attention, and executive functioning domains. We included 80 patients (age 60\u2009\u00b1\u200911\u2009years, 72 (90%) male). MoCA scores increased significantly between hospital admission and 3\u2009months (\u0394MoCA<jats:sub>hospital\u20103M<\/jats:sub>\u2009=\u20092.89, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), but not between 3 and 12\u2009months (\u0394MoCA<jats:sub>3M\u201312M<\/jats:sub>\u2009=\u20090.38, <jats:italic>p<\/jats:italic>\u2009=\u20090.52). Connectivity within the DMN, SN, and dorsal attention network (DAN) was positively related to global cognitive functioning during hospital admission (<jats:italic>\u03b2<\/jats:italic><jats:sub>DMN<\/jats:sub>\u2009=\u20090.85, <jats:italic>p<\/jats:italic>\u2009=\u20090.03; <jats:italic>\u03b2<\/jats:italic><jats:sub>SN<\/jats:sub>\u2009=\u20091.48, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>\u03b2<\/jats:italic><jats:sub>DAN<\/jats:sub>\u2009=\u20090.96, <jats:italic>p<\/jats:italic>\u2009=\u20090.01), but not at 3 and 12\u2009months. Network connectivity was also unrelated to long\u2010term memory, attention, or executive functioning. Resting\u2010state functional connectivity in the DMN, SN, and DAN measured in the first month after cardiac arrest is related to short\u2010term global, but not long\u2010term global or domain\u2010specific cognitive performance of survivors. These results do not support the value of functional connectivity within these RSNs for prediction of long\u2010term cognitive performance after cardiac arrest.<\/jats:p>","DOI":"10.1002\/hbm.26769","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T04:30:43Z","timestamp":1729830643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Functional connectivity in resting\u2010state networks relates to short\u2010term global cognitive functioning in cardiac arrest survivors"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5025-5867","authenticated-orcid":false,"given":"Marlous M. L. H.","family":"Verhulst","sequence":"first","affiliation":[{"name":"Clinical Neurophysiology, TechMed Centre University of Twente  Enschede The Netherlands"},{"name":"Department of Neurology Rijnstate Hospital  Arnhem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanneke M.","family":"Keijzer","sequence":"additional","affiliation":[{"name":"Department of Neurology Rijnstate Hospital  Arnhem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline C. W.","family":"van Gils","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology, TechMed Centre University of Twente  Enschede The Netherlands"},{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience Maastricht University  Maastricht The Netherlands"},{"name":"Limburg Brain Injury Center Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.","family":"van Heugten","sequence":"additional","affiliation":[{"name":"Limburg Brain Injury Center Maastricht University  Maastricht The Netherlands"},{"name":"Department of Neuropsychology and Psychopharmacology Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick J. A.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart A. R.","family":"Tonino","sequence":"additional","affiliation":[{"name":"Department of Radiology Rijnstate Hospital  Arnhem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith L.","family":"Bonnes","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thijs S. R.","family":"Delnoij","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette","family":"Hofmeijer","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology, TechMed Centre University of Twente  Enschede The Netherlands"},{"name":"Department of Neurology Rijnstate Hospital  Arnhem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick C.","family":"Helmich","sequence":"additional","affiliation":[{"name":"Donders Institute for Brain, Cognition and Behaviour, Centre of Expertise for Parkinson and Movement Disorders, Neurology Department Radboud University Medical Centre  Nijmegen The Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging Radboud University  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390590949287"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(09)71511-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2003.822821"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.08.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2010.10.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2022.02.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad181"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00280"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-00087-5_20"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww241"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03074767"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184661"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0235-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2340\/jrm.v55.3497"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2011.00013"},{"key":"e_1_2_9_18_1","unstructured":"Gorgolewski K. 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