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In asymptomatic middle\u2010aged apolipoprotein \u03b54 (\u0391POE4) carriers, who are at higher risk of future AD, study reports are discordant with limited evidence of brain structural differences between carriers and non\u2010carriers of the \u03b54 allele. Alternative imaging markers with higher sensitivity at the presymptomatic stage, ideally quantified using typically acquired structural MRI scans, would thus be of great benefit for the detection of early disease, disease monitoring and subject stratification. In the present cross\u2010sectional study, we investigated textural properties of T1\u2010weighted 3T MRI scans in relation to APOE4 genotype, age and sex. We pooled together data from the PREVENT\u2010Dementia and ALFA studies focused on midlife healthy populations with dementia risk factors (analysable cohort: 1585 participants; mean age 56.2 \u00b1 7.4\u2009years). Voxel\u2010based and texture (examined features: contrast, entropy, energy, homogeneity) based morphometry was used to identify areas of volumetric and textural differences between APOE4 carriers and non\u2010carriers. Textural maps were generated and were subsequently harmonised using voxel\u2010wise COMBAT. For all analyses, APOE4, sex, age and years of education were used as model predictors. Interactions between APOE4 and age were further examined. There were no group differences in regional brain volume or texture based on APOE4 carriership or when age\u2009\u00d7\u2009APOE4 interactions were examined. Older people tended to have a less homogeneous textural profile in grey and white matter and a more homogeneous profile in the ventricles. A more heterogeneous textural profile was observed for females in areas such as the ventricles, frontal and parietal lobes and for males in the brainstem, cerebellum, precuneus and cingulate. Overall, we have shown the absence of volumetric and textural differences between APOE4 carriers and non\u2010carriers at midlife and have established associations of textural features with ageing and sex.<\/jats:p>","DOI":"10.1002\/hbm.26798","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T07:27:09Z","timestamp":1722410829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Texture\u2010based morphometry in relation to apolipoprotein \u03b54 genotype, ageing and sex in a midlife population"],"prefix":"10.1002","volume":"45","author":[{"given":"Maria\u2010Eleni","family":"Dounavi","sequence":"first","affiliation":[{"name":"Department of Psychiatry School of Clinical Medicine, University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah","family":"Mak","sequence":"additional","affiliation":[{"name":"Department of Psychiatry 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