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Recent studies, however, emphasize the role of implicit emotion regulation, particularly implicating the ventromedial prefrontal cortex (VMPFC) in association with its implementation. This study delves into the nuanced role of the VMPFC through focality\u2010optimized multichannel transcranial direct current stimulation (tDCS), shedding light on its causal involvement in implicit reappraisal. The primary goal was to evaluate the effectiveness of VMFPC\u2010targeted tDCS and elucidate its role in individuals with high trait anxiety. Participants engaged in implicit and explicit emotion regulation tasks during multichannel tDCS targeting the VMPFC. The outcome measures encompassed negative emotion ratings, pupillary diameter, and saccade count, providing a comprehensive evaluation of emotion regulation efficiency. The intervention exhibited a notable impact, resulting in significant reductions in negative emotion ratings and pupillary reactions during implicit reappraisal, highlighting the indispensable role of the VMPFC in modulating emotional responses. Notably, these effects demonstrated sustained efficacy up to 1\u2009day postintervention. This study underscores the potency of VMPFC\u2010targeted multichannel tDCS in augmenting implicit emotion regulation. This not only contributes insights into the neural mechanisms of emotion regulation but also suggests innovative therapeutic avenues for anxiety disorders. The findings present a promising trajectory for future mood disorder interventions, bridging the gap between implicit emotion regulation and neural stimulation techniques.<\/jats:p>","DOI":"10.1002\/hbm.26812","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T11:07:40Z","timestamp":1725966460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The ventromedial prefrontal cortex plays an important role in implicit emotion regulation: A focality\u2010optimized multichannel <scp>tDCS<\/scp> study in anxiety individuals"],"prefix":"10.1002","volume":"45","author":[{"given":"Kexiang","family":"Gao","sequence":"first","affiliation":[{"name":"Institute of Brain and Psychological Sciences Sichuan Normal University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslan B.","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute of Brain and Psychological Sciences Sichuan Normal University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijin","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Brain and Psychological Sciences Sichuan Normal University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Brain and Psychological Sciences Sichuan Normal University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1825-7114","authenticated-orcid":false,"given":"Dandan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Brain and Psychological Sciences Sichuan Normal University  Chengdu China"},{"name":"China Center for Behavioral Economics and Finance &amp; School of Economics Southwestern University of Finance and Economics  Chengdu China"},{"name":"School of Psychology, Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12787"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0063-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3321\/j.issn:1000-6729.2005.11.001"},{"key":"e_1_2_9_5_1","volume-title":"Beck depression inventory","author":"Beck A. 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