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In order to truly know if such findings have widespread applicability, multicenter methods and studies are needed. To address this, members of the North American Imaging in MS (NAIMS) Cooperative worked together to create a multicenter collaborative study of 7\u2009T MRI in MS. In this manuscript, we describe the methods we have developed for the purpose of pooling together a large, retrospective dataset of 7\u2009T MRIs acquired in multiple MS studies at five institutions. To date, this group has contributed five\u2010hundred and twenty\u2010eight 7\u2009T MRI scans from 350 individuals with MS to a common data repository, with plans to continue to increase this sample size in the coming years. We have developed unified methods for image processing for data harmonization and lesion identification\/segmentation. We report here our initial observations on intersite differences in acquisition, which includes site\/device differences in brain coverage and image quality. We also report on the development of our methods and training of image evaluators, which resulted in median Dice Similarity Coefficients for trained raters' annotation of cortical and deep gray matter lesions, paramagnetic rim lesions, and meningeal enhancement between 0.73 and 0.82 compared to final consensus masks. We expect this publication to act as a resource for other investigators aiming to combine multicenter 7\u2009T MRI datasets for the study of MS, in addition to providing a methodological reference for all future analysis projects to stem from the development of this dataset.<\/jats:p>","DOI":"10.1002\/hbm.26816","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T04:51:54Z","timestamp":1724302314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pooled analysis of multiple sclerosis findings on multisite 7 Tesla <scp>MRI<\/scp>: Protocol and initial observations"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-2004","authenticated-orcid":false,"given":"Daniel M.","family":"Harrison","sequence":"first","affiliation":[{"name":"Department of Neurology University of Maryland School of Medicine  Baltimore Maryland USA"},{"name":"Department of 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