{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:04:08Z","timestamp":1791050648784,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KO 1598\/6\u20101"],"award-info":[{"award-number":["KO 1598\/6\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LO 795\/25\u20101"],"award-info":[{"award-number":["LO 795\/25\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In temporomandibular disorder (TMD), the effects of standard interventions such as using an occlusal splint and its impact on pain relief and pain catastrophizing are poorly understood. Earlier work pointed to a crucial role of insula activation with changes in pain relief by occlusal splint treatment. We performed a functional imaging study using specially developed splint systems to allow for a placebo\u2010controlled longitudinal design. Using functional MRI we examined 20 TMD patients during repetitive occlusal movements at baseline and over the course of splint therapy and also collected self\u2010reported pain catastrophizing. For balancing performance between baseline and after intervention we used occlusion force measures in an individualized fMRI\u2010splint system. Splint therapy lasted for approximately 7\u2009weeks with one group selected by randomization wearing a palatine placebo splint over the first 3\u2009weeks (delayed start; 11 individuals). As expected, fMRI activation in areas involved in pain processing (insula, primary and secondary somatosensory cortex) decreased with intervention. At baseline a positive correlation between activation of the left anterior insula and pain catastrophizing was present. Both parameters decreased over intervention while associations were primarily observable for patients with rather mild TMD.<\/jats:p>","DOI":"10.1002\/hbm.70051","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T12:09:42Z","timestamp":1729339782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pain Catastrophizing and Functional Activation During Occlusion in <scp>TMD<\/scp> Patients\u2014An Interventional Study"],"prefix":"10.1002","volume":"45","author":[{"given":"K.","family":"Klepzig","sequence":"first","affiliation":[{"name":"Functional Imaging Unit, Center of Diagnostic Radiology and Neuroradiology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Domin","sequence":"additional","affiliation":[{"name":"Functional Imaging Unit, Center of Diagnostic Radiology and Neuroradiology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kordass","sequence":"additional","affiliation":[{"name":"Department of Dental Radiology, Centre of Dentistry and Oral Health University Medicine Greifswald  Greifswald Germany"},{"name":"Department of Clinical Dental CAD\/CAM and CMD\u2010Treatment, Centre of Dentistry and Oral Health University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4519-4956","authenticated-orcid":false,"given":"M.","family":"Lotze","sequence":"additional","affiliation":[{"name":"Functional Imaging Unit, Center of Diagnostic Radiology and Neuroradiology University Medicine Greifswald  Greifswald 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