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McDonnell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000143","name":"Alzheimer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Early stages of Alzheimer's disease (AD) are associated with volume reductions in specific subregions of the medial temporal lobe (MTL). Using a manual segmentation method\u2014the Olsen\u2013Amaral\u2013Palombo (OAP) protocol\u2014previous work in healthy older adults showed that reductions in grey matter volumes in MTL subregions were associated with lower scores on the Montreal Cognitive Assessment (MoCA), suggesting atrophy may occur prior to diagnosis of mild cognitive impairment, a condition that often progresses to AD. However, current \u201cgold standard\u201d manual segmentation methods are labour intensive and time consuming. Here, we examined the utility of Automatic Segmentation of Hippocampal Subfields (ASHS) to detect volumetric differences in MTL subregions of healthy older adults who varied in cognitive status as determined by the MoCA. We trained ASHS on the OAP protocol to create the ASHS\u2010OAP atlas and then examined how well automated segmentation replicated manual segmentation. Volumetric measures obtained from the ASHS\u2010OAP atlas were also contrasted against those from the ASHS\u2010PMC atlas, a widely used atlas provided by the ASHS team. The pattern of volumetric results was similar between the ASHS\u2010OAP atlas and manual segmentation for anterolateral entorhinal cortex and perirhinal cortex, suggesting that ASHS\u2010OAP is a viable alternative to current manual segmentation methods for detecting group differences based on cognitive status. Although ASHS\u2010OAP and ASHS\u2010PMC produced varying volumes for most regions of interest, they both identified early signs of neurodegeneration in CA<jats:sub>2<\/jats:sub>\/CA<jats:sub>3<\/jats:sub>\/DG and identified marginal differences in entorhinal cortex. Our findings highlight the utility of automated segmentation methods but still underscore the need for a unified and harmonized MTL segmentation atlas.<\/jats:p>","DOI":"10.1002\/hbm.70054","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T08:44:41Z","timestamp":1729845881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Segmentation Method on Medial Temporal Lobe Subregion Volumes in Aging"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8149-6858","authenticated-orcid":false,"given":"Negar","family":"Mazloum\u2010Farzaghi","sequence":"first","affiliation":[{"name":"Department of Psychology University of Toronto  Toronto Ontario Canada"},{"name":"Rotman Research Institute Baycrest Academy for Research and Education  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan\u00a0D.","family":"Barense","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Toronto  Toronto Ontario Canada"},{"name":"Rotman Research Institute Baycrest Academy for Research and Education  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer\u00a0D.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Toronto  Toronto Ontario Canada"},{"name":"Rotman Research Institute Baycrest Academy for Research and Education  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig\u00a0E.\u00a0L.","family":"Stark","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior University of California Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-4152","authenticated-orcid":false,"given":"Rosanna\u00a0K.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Toronto  Toronto Ontario Canada"},{"name":"Rotman Research Institute Baycrest Academy for Research and Education  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1575","article-title":"Morphology of the Inner Structure of the Hippocampal Formation in Alzheimer Disease","volume":"24","author":"Adachi M.","year":"2003","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23891"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152982.47274.9E"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20104580(95)00021\u20106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz123"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","unstructured":"Buckner R. L. D. Head J. Parker et al. 2004. \u201cA Unified Approach for Morphometric and Functional Data Analysis in Young Old and Demented Adults Using Automated Atlas\u2010Based Head Size Normalization: Reliability and Validation Against Manual Measurement of Total Intracranial Volume.\u201dNeuroimage23: 724\u2013738.","DOI":"10.1016\/j.neuroimage.2004.06.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030304"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2006.880587"},{"key":"e_1_2_9_10_1","first-page":"1e24","article-title":"The Effectiveness of Unitization in Mitigating Age\u2010Related Relational Learning Impairments Depends on Existing Cognitive Status","volume":"5585","author":"D'Angelo M. 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