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The goal of this study was to determine how structural brain aging is influenced by hearing loss. Human Connectome Project Aging data were analyzed, including T1\u2010weighted Magnetic Resonance Imaging (MRI) and Words in noise (WIN) thresholds (<jats:italic>n<\/jats:italic>\u2009=\u2009623). Freesurfer extracted gray and white matter volume, and cortical thickness, area, and curvature. Linear regression models targeted (1) interactions between age and WIN threshold and (2) correlations with WIN threshold adjusted for age, both corrected for false discovery rate (p<jats:sub>FDR<\/jats:sub>\u2009&lt;\u20090.05). WIN threshold moderated age\u2010related increase in volume in bilateral inferior lateral ventricles, with a higher threshold associated with increased age\u2010related ventricle expansion. Age\u2010related differences in the occipital cortex also increased with higher WIN thresholds. When controlling for age, high WIN threshold was correlated with reduced cortical thickness in Heschl's gyrus, calcarine sulcus, and other sensory regions, and reduced temporal lobe white matter. Older volunteers with poorer hearing and cognitive scores had the lowest volume in left parahippocampal white matter. These results suggest that better hearing is associated with reduced age\u2010related differences in medial temporal lobe, while better hearing at any age is associated with greater cortical tissue in auditory and other sensory regions. Future longitudinal studies are needed to assess the causal nature of these relationships, but these results indicate interventions that preserve or protect hearing function may combat some neurodegenerative changes in aging.<\/jats:p>","DOI":"10.1002\/hbm.70074","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T09:40:56Z","timestamp":1731577256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hearing Function Moderates Age\u2010Related Differences in Brain Morphometry in the <scp>HCP<\/scp> Aging Cohort"],"prefix":"10.1002","volume":"45","author":[{"given":"Robert M.","family":"Kirschen","sequence":"first","affiliation":[{"name":"Department of Radiology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1518-0708","authenticated-orcid":false,"given":"Amber 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