{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:50:08Z","timestamp":1773971408257,"version":"3.50.1"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022663","name":"M\u00e4xi-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["3200B0\u2010108176"],"award-info":[{"award-number":["3200B0\u2010108176"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The human brain connectome is characterized by the duality of highly modular structure and efficient integration, supporting information processing. Newborns with congenital heart disease (CHD), prematurity, or spina bifida aperta (SBA) constitute a population at risk for altered brain development and developmental delay (DD). We hypothesize that, independent of etiology, alterations of connectomic organization reflect neural circuitry impairments in cognitive DD. Our study aim is to address this knowledge gap by using a multi\u2010etiologic neonatal dataset to reveal potential commonalities and distinctions in the structural brain connectome and their associations with DD. We used diffusion tensor imaging of 187 newborns (42 controls, 51 with CHD, 51 with prematurity, and 43 with SBA). Structural weighted connectomes were constructed using constrained spherical deconvolution\u2010based probabilistic tractography and the Edinburgh Neonatal Atlas. Assessment of brain network topology encompassed the analysis of global graph features, network\u2010based statistics, and low\u2010dimensional representation of global and local graph features. The Cognitive Composite Score of the Bayley scales of Infant and Toddler Development 3rd edition was used as outcome measure at corrected 2\u2009years for the preterm born individuals and SBA patients, and at 1\u2009year for the healthy controls and CHD. We detected differences in the connectomic structure of newborns across the four groups after visualizing the connectomes in a two\u2010dimensional space defined by network integration and segregation. Further, analysis of covariance analyses revealed differences in global efficiency (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), modularity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), mean rich club coefficient (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.017), and small\u2010worldness (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016) between groups after adjustment for postmenstrual age at scan and gestational age at birth. Moreover, small\u2010worldness was significantly associated with poorer cognitive outcome, specifically in the CHD cohort (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.41,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005). Our cross\u2010etiologic study identified divergent structural brain connectome profiles linked to deviations from optimal network integration and segregation in newborns at risk for DD. Small\u2010worldness emerges as a key feature, associating with early cognitive outcomes, especially within the CHD cohort, emphasizing small\u2010worldness' crucial role in shaping neurodevelopmental trajectories. Neonatal connectomic alterations associated with DD may serve as a marker identifying newborns at\u2010risk for DD and provide early therapeutic interventions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT 00313946\n                  <\/jats:p>","DOI":"10.1002\/hbm.70084","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:01:31Z","timestamp":1736485291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Altered Connectome Topology in Newborns at Risk for Cognitive Developmental Delay: A Cross\u2010Etiologic Study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4728-6381","authenticated-orcid":false,"given":"Anna","family":"Speckert","sequence":"first","affiliation":[{"name":"Center for MR Research University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Neuroscience Center Zurich University of Zurich  Zurich Switzerland"},{"name":"URPP Adaptive Brain Circuits in Development and Learning University of Zurich  Zurich Switzerland"},{"name":"University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Payette","sequence":"additional","affiliation":[{"name":"Center for MR Research University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Knirsch","sequence":"additional","affiliation":[{"name":"University of Zurich  Zurich Switzerland"},{"name":"Children's Research Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Pediatric Heart Center, Pediatric Cardiology University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"von Rhein","sequence":"additional","affiliation":[{"name":"URPP Adaptive Brain Circuits in Development and Learning University of Zurich  Zurich Switzerland"},{"name":"Child Development Center University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Grehten","sequence":"additional","affiliation":[{"name":"Children's Research Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"The Zurich Center for Fetal Diagnosis and Therapy  Zurich Switzerland"},{"name":"Zurich Center for Spina Bifida University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Department of Diagnostic Imaging University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimund","family":"Kottke","sequence":"additional","affiliation":[{"name":"Children's Research Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"The Zurich Center for Fetal Diagnosis and Therapy  Zurich Switzerland"},{"name":"Zurich Center for Spina Bifida University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Department of Diagnostic Imaging University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Hagmann","sequence":"additional","affiliation":[{"name":"Children's Research Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Zurich Center for Spina Bifida University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Department of Neonatology University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Natalucci","sequence":"additional","affiliation":[{"name":"University of Zurich  Zurich Switzerland"},{"name":"Larsson\u2010Rosenquist Center for Neurodevelopment, Growth and Nutrition of the Newborn University Hospital Zurich and University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ueli","family":"Moehrlen","sequence":"additional","affiliation":[{"name":"University of Zurich  Zurich Switzerland"},{"name":"The Zurich Center for Fetal Diagnosis and Therapy  Zurich Switzerland"},{"name":"Zurich Center for Spina Bifida University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Department for Pediatric Surgery University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Mazzone","sequence":"additional","affiliation":[{"name":"University of Zurich  Zurich Switzerland"},{"name":"Children's Research Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"The Zurich Center for Fetal Diagnosis and Therapy  Zurich Switzerland"},{"name":"Zurich Center for Spina Bifida University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Ochsenbein\u2010K\u00f6lble","sequence":"additional","affiliation":[{"name":"University of Zurich  Zurich Switzerland"},{"name":"The Zurich Center for Fetal Diagnosis and Therapy  Zurich Switzerland"},{"name":"Department of Obstetrics University Hospital of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Padden","sequence":"additional","affiliation":[{"name":"Children's Research Center University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Zurich Center for Spina Bifida University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Division of Pediatric Rehabilitation University Children's Hospital Zurich  Zurich Switzerland"},{"name":"Spina Bifida Study Group Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"SPINA BIFIDA STUDY GROUP 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