{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:27:55Z","timestamp":1781605675802,"version":"3.54.5"},"reference-count":85,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41EB015922"],"award-info":[{"award-number":["P41EB015922"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","award":["2020\u2010225670"],"award-info":[{"award-number":["2020\u2010225670"]}],"id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32AG058507"],"award-info":[{"award-number":["T32AG058507"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005380","name":"American Neurotology Society","doi-asserted-by":"publisher","award":["GR1053368"],"award-info":[{"award-number":["GR1053368"]}],"id":[{"id":"10.13039\/100005380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN275200900018C"],"award-info":[{"award-number":["HHSN275200900018C"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2024,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Auditory perception is established through experience\u2010dependent stimuli exposure during sensitive developmental periods; however, little is known regarding the structural development of the central auditory pathway in humans. The present study characterized the regional developmental trajectories of the ascending auditory pathway from the brainstem to the auditory cortex from infancy through adolescence using a novel diffusion MRI\u2010based tractography approach and along\u2010tract analyses. We used diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) to quantify the magnitude and timing of auditory pathway microstructural maturation. We found spatially varying patterns of white matter maturation along the length of the tract, with inferior brainstem regions developing earlier than thalamocortical projections and left hemisphere tracts developing earlier than the right. These results help to characterize the processes that give rise to functional auditory processing and may provide a baseline for detecting abnormal development.<\/jats:p>","DOI":"10.1002\/hbm.70091","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T02:21:36Z","timestamp":1734315696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Spatial Organization of Ascending Auditory Pathway Microstructural Maturation From Infancy Through Adolescence Using a Novel Fiber Tracking Approach"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3976-5783","authenticated-orcid":false,"given":"Kirsten M.","family":"Lynch","sequence":"first","affiliation":[{"name":"Laboratory of Neuro Imaging (LONI), USC Mark and Mary Stevens Institute for Neuroimaging and Informatics USC Keck School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie C.","family":"Bodison","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy, College of Public Health and Health Professions University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Cabeen","sequence":"additional","affiliation":[{"name":"Laboratory of Neuro Imaging (LONI), USC Mark and Mary Stevens Institute for Neuroimaging and Informatics USC Keck School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Toga","sequence":"additional","affiliation":[{"name":"Laboratory of Neuro Imaging (LONI), USC Mark and Mary Stevens Institute for Neuroimaging and Informatics USC Keck School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney C. J.","family":"Voelker","sequence":"additional","affiliation":[{"name":"Otology\/Neurotology Pacific Neuroscience Institute  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp042"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.08.015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374709-9.00006-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2016.00030"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6623091"},{"key":"e_1_2_10_11_1","unstructured":"Cabeen R. P. D. H.Laidlaw andA. W.Toga.2018.\u201cQuantitative Imaging Toolkit: Software for Interactive 3D Visualization Data Exploration and Computational Analysis of Neuroimaging Datasets.\u201din:ISMRM\u2010ESMRMB Abstracts. 12\u201314."},{"key":"e_1_2_10_12_1","unstructured":"Cabeen R. P. F.Sepehrband andA. W.Toga.2019.\u201cRapid and Accurate NODDI Parameter Estimation With the Spherical Mean Technique.\u201din:Proc International Society for Magnetic Resonance in Medicine(ISMRM). 3363."},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","unstructured":"Cabeen R. P. andA. W.Toga.2020.\u201cReinforcement Tractography: A Hybrid Approach for Robust Segmentation of Complex Fiber Bundles.\u201din:IEEE 17th International Symposium on Biomedical Imaging(ISBI). 999\u20131003.","DOI":"10.1109\/ISBI45749.2020.9098371"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021\u2010020\u201009488\u20102"},{"key":"e_1_2_10_15_1","unstructured":"Cabeen R. P. E.Kari C.Volker et\u00a0al.2018.\u201cFeasibility of Quantitative Diffusion MR Tractography of the Vestibulocochlear Nerve in Children With Unilateral Profound Sensorineural Hearing Loss.\u201dProceedings of the International Society for Magnetic Resonance in Medicine(ISMRM)."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2016.00009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.04.187"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2379"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.428656"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.383691"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00400"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2020.09.003"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00764"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.01.023"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217118"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4306.1402"},{"key":"e_1_2_10_29_1","unstructured":"Holland S. V. J.Schmithorst M.Wagner et\u00a0al.2015.\u201cThe C\u2010MIND Project: Normative MRI and Behavioral Data From Children From Birth to 18\u2009Years.\u201din:Proceedings of the 21st Annumal Meeting of the Organization for Human Brain Mapping(OHBM): Honolulu HA."},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.09.053.Optimization"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140643"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1992.tb00939.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010014\u20109327\u20107"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2014145117"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072\u2010198805000\u201000003"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010080317\u2010061513"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.09.017"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(88)90773\u20109"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5302\u201010.2011"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.12.097"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.094"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3778"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.053"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201000908\u20107"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.40232"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446\u2010199902000\u201000008"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116672"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182340"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114362"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.043"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101620010052"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004290050021"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000711"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992020701383019"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20105955(95)00218\u20109"},{"key":"e_1_2_10_57_1","first-page":"27","volume-title":"Introduction to Diffusion Tensor Imaging: And Higher Order Models","author":"Mori S.","year":"2013"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.12.021"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318281e215"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.451"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz001"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22055"},{"key":"e_1_2_10_63_1","volume-title":"Neuroanatomy, Auditory Pathway","author":"Peterson D. C.","year":"2021"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.01.061"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000201049.66073.8d"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.5.570"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2011.07685.x.The"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht152"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.005"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1267"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.051"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0034999"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.01.010"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2301021640"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010019\u201005477\u20107"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn173"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.12.025"},{"key":"e_1_2_10_79_1","first-page":"3","volume-title":"Regional Development of the Brain in Early Life","author":"Yakovlev P.","year":"1967"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.08.021.Secreted"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.64.2.465"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.02.014"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2007.906784"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.072"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.01.046"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.008"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.70091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.70091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.70091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:19:29Z","timestamp":1772979569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.70091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,15]]},"references-count":85,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2024,12,15]]}},"alternative-id":["10.1002\/hbm.70091"],"URL":"https:\/\/doi.org\/10.1002\/hbm.70091","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.06.10.597798","asserted-by":"object"}]},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,15]]},"assertion":[{"value":"2024-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70091"}}