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The objective of this study was to investigate the relationship between DBS\u2010induced changes in functional connectivity at rest and modulation of response\u2010 and movement inhibition by STN\u2010DBS in a visuomotor task involving high conflict. During DBS ON and OFF conditions, we conducted a visuomotor task in 14 PD patients who previously underwent resting\u2010state functional MRI (rs\u2010fMRI) acquisitions DBS ON and OFF as part of a different study. In the task, participants had to move a cursor with a pen on a digital tablet either toward (automatic condition) or in the opposite direction (controlled condition) of a target. STN\u2010DBS induced modulation of resting\u2010state functional connectivity (RSFC) as a function of changes in behavior ON versus OFF DBS was estimated using link\u2010wise network\u2010based statistics. Behavioral results showed diminished reaction time adaptation and higher pen\u2010to\u2010target movement velocity under DBS. Reaction time reduction was associated with attenuated functional connectivity between cortical motor areas, basal ganglia, and thalamus. On the other hand, increased movement velocity ON DBS was associated with stronger pallido\u2010thalamic connectivity. These findings suggest that decoupling of a motor cortico\u2010basal ganglia network underlies impaired inhibitory control in PD patients undergoing subthalamic DBS and highlight the concept of functional network modulation through DBS.<\/jats:p>","DOI":"10.1002\/hbm.70095","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T09:52:19Z","timestamp":1733824339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in Functional Connectivity Relate to Modulation of Cognitive Control by Subthalamic Stimulation"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0657-6516","authenticated-orcid":false,"given":"Johannes","family":"Achtzehn","sequence":"first","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Berlin Institute of Health (BIH)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Grospietsch","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"G\u00fcttler","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Center for Brain Circuit Therapeutics, Department of Neurology Brigham &amp; 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