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Mapping"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting\u2010state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data\u2010driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis\u2010driven examinations of ROIs or canonical networks. Therefore, the current study used group independent components analysis (ICA) and graph theory principles to identify, characterize, and subsequently compare brain network dynamics and recurrent connectivity states in a large sample of trauma exposed individuals (<jats:italic>N<\/jats:italic>\u2009=\u20091035) with and without PTSD from the ENIGMA\u2010PGC PTSD workgroup. Neither static FC nor dynamic FC results showed robust differences between groups. There were also no group differences in dwell time or number of transitions of recurrent connectivity states. This multi\u2010cohort sample with heterogenous trauma types and demographic features offers a significantly larger scale approach than prior literature with smaller homogenous trauma cohorts. Heterogeneity of PTSD, especially within diffuse brain networks, may not be captured by evaluating only diagnostic groups, further work should be done to evaluate brain network dynamics with respect to specific symptom profiles and trauma types.<\/jats:p>","DOI":"10.1002\/hbm.70116","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:00:34Z","timestamp":1753880434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Data\u2010Driven Approach to Dynamic Resting State Functional Connectivity in Post\u2010Traumatic Stress Disorder: An <scp>ENIGMA<\/scp>\u2010<scp>PGC PTSD<\/scp> Study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9199-8632","authenticated-orcid":false,"given":"Carissa W.","family":"Tomas","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Social Sciences Institute of Health and Equity, Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Comprehensive Injury Center Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-4067","authenticated-orcid":false,"given":"Jacklynn M.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Psychology Marquette University  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Lexi","family":"Baird","sequence":"additional","affiliation":[{"name":"Brain Imaging and Analysis Center Duke University  Durham North Carolina USA"},{"name":"Department of Veteran Affairs Mid\u2010Atlantic Mental Illness Research Education and Clinical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney C.","family":"Haswell","sequence":"additional","affiliation":[{"name":"Brain Imaging and Analysis Center Duke University  Durham North Carolina USA"},{"name":"Department of Veteran Affairs Mid\u2010Atlantic Mental Illness Research Education and Clinical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5783-6181","authenticated-orcid":false,"given":"Chadi G.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Division of Psychiatry Baylor College of Medicine  Houston Texas USA"},{"name":"Departments of Psychiatry and Psychology Yale 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