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Characterizing thalamic nuclei non\u2010invasively with structural MRI is particularly relevant for patient populations with Parkinson's disease, epilepsy, dementia, and schizophrenia. However, severe head motion in these populations poses a significant challenge for in\u00a0vivo mapping of thalamic nuclei. Recent advancements have leveraged the compressed sensing (CS) framework to accelerate structural MRI acquisition times in MPRAGE sequence variants, while fast segmentation tools like FastSurfer have reduced processing times in neuroimaging research. In this study, we evaluated thalamic nuclei segmentations derived from six different MPRAGE variants with varying degrees of CS acceleration (from about 9 to about 1\u2010min acquisitions). Thalamic segmentations were initialized from either FastSurfer or FreeSurfer, and the robustness of the thalamic nuclei segmentation tool to different initialization inputs was evaluated. Our findings show minimal sequence effects with no systematic bias, and low volume variability across sequences for the whole thalamus and major thalamic nuclei. Notably, CS\u2010accelerated sequences produced less variable volumes compared to non\u2010CS sequences. Additionally, segmentations of thalamic nuclei initialized from FastSurfer and FreeSurfer were highly comparable. We provide the first evidence supporting that a good segmentation quality of thalamic nuclei with CS T1\u2010weighted image acceleration in a clinical 3T MRI system is possible. Our findings encourage future applications of fast T1\u2010weighted MRI to study deep gray matter. CS\u2010accelerated sequences and rapid segmentation methods are promising tools for future studies aiming to characterize thalamic nuclei in\u00a0vivo at 3T in both healthy individuals and clinical populations.<\/jats:p>","DOI":"10.1002\/hbm.70120","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:40:17Z","timestamp":1735173617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Advancing Thalamic Nuclei Segmentation: The Impact of Compressed Sensing on\n                    <scp>MRI<\/scp>\n                    Processing"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0791-5882","authenticated-orcid":false,"given":"Sebastian","family":"H\u00fcbner","sequence":"first","affiliation":[{"name":"Center for Mind\/Brain Sciences\u2014CIMeC University of Trento  Rovereto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Tambalo","sequence":"additional","affiliation":[{"name":"Center for Mind\/Brain Sciences\u2014CIMeC University of Trento  Rovereto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Novello","sequence":"additional","affiliation":[{"name":"Center for Mind\/Brain Sciences\u2014CIMeC University of Trento  Rovereto Italy"},{"name":"Data Science for Health Fondazione Bruno Kessler  Trento Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Hilbert","sequence":"additional","affiliation":[{"name":"Advanced Clinical Imaging Technology Siemens Healthineers International AG  Lausanne Switzerland"},{"name":"Department of Radiology Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"},{"name":"Signal Processing Laboratory 5 (LTS5) Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Kober","sequence":"additional","affiliation":[{"name":"Advanced Clinical Imaging Technology Siemens Healthineers International AG  Lausanne Switzerland"},{"name":"Department of Radiology Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"},{"name":"Signal Processing Laboratory 5 (LTS5) Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Jovicich","sequence":"additional","affiliation":[{"name":"Center for Mind\/Brain Sciences\u2014CIMeC University of Trento  Rovereto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-021-00933-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000139"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730\u2010725x(93)90218\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.02.041"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1075"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513478675"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30048-5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/CBMS52027.2021.00096"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24856"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.2.191"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0404-0"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn278"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/450341"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-020-00906-9"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIT.2006.871582"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184661"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmp.2022.10.023"},{"key":"e_1_2_10_20_1","unstructured":"Ferris C. 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