{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:58:54Z","timestamp":1792000734809,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Over a third of minor stroke patients experience post\u2010stroke cognitive impairment (PSCI), but no validated tools exist to identify at\u2010risk patients early. This study investigated whether disconnection features derived from infarcts and white matter hyperintensities (WMH) could serve as markers for short\u2010 and long\u2010term cognitive decline in first\u2010ever minor ischemic stroke patients. First\u2010ever minor ischemic stroke patients (NIHSS\u2009\u2264\u20097) were prospectively followed at 72\u2010h, 6\u2009months, and 36\u2009months post\u2010stroke with cognitive tests and brain MRI. Infarct and WMH volumes were semi\u2010automatically assessed on DWI and FLAIR sequences. Bayesian tract\u2010based disconnection models estimated remote pathological effects of infarcts and WMH. Associations between disconnection features and cognitive outcomes were analyzed using canonical correlation analyses, adjusted for age, education, and multiple comparisons. Among 105 patients (31% female, mean age 63\u2009\u00b1\u200912\u2009years), infarct volume averaged 10.28\u2009\u00b1\u200917.10\u2009cm<jats:sup>3<\/jats:sup> and predominantly involved the middle cerebral artery territory (83%). WMH burden was higher in frontal periventricular white matter. Infarct\u2010based features did not significantly relate to PCSI. However, a WMH\u2010derived disconnection factor, involving commissural and frontal tracts, and the right superior longitudinal fasciculus, was significantly associated with PSCI at 6\u2009months (OR\u2009=\u20099.96, <jats:italic>p<\/jats:italic> value\u2009=\u20090.02) and 36\u2009months (OR\u2009=\u200912.27, <jats:italic>p<\/jats:italic> value\u2009=\u20090.006), particularly in executive\/attention, language, and visuospatial domains. This factor, unrelated to WMH volume, outperformed demographic and clinical predictors of PSCI. WMH\u2010induced disconnection may be associated with short\u2010 and long\u2010term PSCI in minor stroke. Routine MR\u2010derived features could identify at\u2010risk patients for rehabilitation trials.<\/jats:p>","DOI":"10.1002\/hbm.70138","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T09:45:32Z","timestamp":1737971132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long\u2010Term Post\u2010Stroke Cognition in Patients With Minor Ischemic Stroke is Related to Tract\u2010Based Disconnection Induced by White Matter Hyperintensities"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2425-2283","authenticated-orcid":false,"given":"Renaud","family":"Lopes","sequence":"first","affiliation":[{"name":"U1172 \u2013 LilNCog (Lille Neuroscience &amp; Cognition) Univ. Lille, Inserm, CHU Lille  Lille France"},{"name":"US 41 \u2013 UAR 2014 \u2013 PLBS Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille  Lille France"},{"name":"Department of Nuclear Medicine CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Kuchcinski","sequence":"additional","affiliation":[{"name":"U1172 \u2013 LilNCog (Lille Neuroscience &amp; Cognition) Univ. Lille, Inserm, CHU Lille  Lille France"},{"name":"US 41 \u2013 UAR 2014 \u2013 PLBS Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille  Lille France"},{"name":"Department of Neuroradiology CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Dondaine","sequence":"additional","affiliation":[{"name":"U1172 \u2013 LilNCog (Lille Neuroscience &amp; Cognition) Univ. Lille, Inserm, CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Duron","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Alphonse de Rothschild Foundation Hospital  Paris France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Paris, PARCC, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Mendyk","sequence":"additional","affiliation":[{"name":"U1172 \u2013 LilNCog (Lille Neuroscience &amp; Cognition) Univ. Lille, Inserm, CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"H\u00e9non","sequence":"additional","affiliation":[{"name":"U1172 \u2013 LilNCog (Lille Neuroscience &amp; Cognition) Univ. Lille, Inserm, CHU Lille  Lille France"},{"name":"Department of Neurology CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cordonnier","sequence":"additional","affiliation":[{"name":"U1172 \u2013 LilNCog (Lille Neuroscience &amp; Cognition) Univ. Lille, Inserm, CHU Lille  Lille France"},{"name":"Department of Neurology CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Pruvo","sequence":"additional","affiliation":[{"name":"U1172 \u2013 LilNCog (Lille Neuroscience &amp; Cognition) Univ. Lille, Inserm, CHU Lille  Lille France"},{"name":"US 41 \u2013 UAR 2014 \u2013 PLBS Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille  Lille France"},{"name":"Department of Neuroradiology CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Bordet","sequence":"additional","affiliation":[{"name":"U1172 \u2013 LilNCog (Lille Neuroscience &amp; Cognition) Univ. Lille, Inserm, CHU Lille  Lille France"},{"name":"Department of Pharmacology CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Leclerc","sequence":"additional","affiliation":[{"name":"U1172 \u2013 LilNCog (Lille Neuroscience &amp; Cognition) Univ. Lille, Inserm, CHU Lille  Lille France"},{"name":"Department of Neuroradiology CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2677-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.537704"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1162\/jmlr.2003.3.4-5.993"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005553"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24877"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2008.04.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2018.10.015"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.03.011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001502"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019895707"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(23)00217-9"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.11.2280"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac105"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.170.3961.940"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011827"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70164-2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.204685"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.100"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102639"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06019-8"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170002691X"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23198"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx114"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2022-002049"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.6968"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008612"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011452"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy332"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.06.004"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.08.031"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70236-4"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30442-3"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.10"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000034"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000251302.55202.73"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.10.006"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa156"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00208"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13616-1"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-010-9130-1"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016676612"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.04.212"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26326"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116158"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1028-5"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00060-0"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.11498"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.027"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1611073113"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00290"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210619"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac388"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006506"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.70138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T08:32:50Z","timestamp":1739262770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.70138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/hbm.70138"],"URL":"https:\/\/doi.org\/10.1002\/hbm.70138","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,27]]},"assertion":[{"value":"2024-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70138"}}