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In this preliminary study with 34 healthy individuals, tDCS was applied to either the left or right DLPFC or a sham group. Behavioral and neurophysiological changes were examined by the Stroop test and resting\u2010state fMRI, respectively, which were measured before and after a 15\u2010min tDCS session. Seed\u2010to\u2010voxel connectivity analysis with seeds placed under the tDCS target regions (F3 and F4) showed no significant changes, but voxel\u2010to\u2010voxel whole\u2010brain intrinsic connectivity (IC) analysis revealed significant 3\u2009\u00d7\u20092 interaction effects (stimulation site \u00d7 time) in the right DLPFC (18\u2009mm off from the F4). Post hoc analysis showed that only the right DLPFC stimulation led to an increase in IC from pre\u2010 to post\u2010stimulation. Consistent with this finding, right DLPFC stimulation improved Stroop task performance measured by increased interference score, which represents better inhibition of irrelevant information. These findings provide further insights into the hemispheric difference of tDCS effects and its underlying neurophysiological mechanisms. However, the small sample size limits the generalizability of the results and necessitates further research with a larger cohort for confirmation.<\/jats:p>","DOI":"10.1002\/hbm.70218","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:18:16Z","timestamp":1746188296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Asymmetric Modulation of Brain Connectivity by Anodal Transcranial Direct Current Stimulation in Healthy Individuals: A Single\u2010Blind, Randomized Sham\u2010Controlled Trial"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-9727","authenticated-orcid":false,"given":"Tiffany","family":"Carther\u2010Krone","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Cell Science, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"},{"name":"PrairieNeuro Research Centre Kleysen Institute for Advanced Medicine, Winnipeg Health Science Centre  Winnipeg Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary A.","family":"McAllister","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Cell Science, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"},{"name":"PrairieNeuro Research Centre Kleysen Institute for Advanced Medicine, Winnipeg Health Science Centre  Winnipeg Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Hyung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Cell Science, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"},{"name":"PrairieNeuro Research Centre Kleysen Institute for Advanced Medicine, Winnipeg Health Science Centre  Winnipeg Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Ryner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9700-7692","authenticated-orcid":false,"given":"Ji Hyun","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Cell Science, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"},{"name":"PrairieNeuro Research Centre Kleysen Institute for Advanced Medicine, Winnipeg Health Science Centre  Winnipeg Canada"},{"name":"Graduate Program in Biomedical Engineering, Price Faculty of Engineering University of Manitoba  Winnipeg Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.12.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2010.06.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0519\u201007.2007"},{"key":"e_1_2_9_5_1","unstructured":"Automated Neuropsychological Assessment Metrics (Version 4) [Computer software].2016.Denver CO:Vista LifeSciences Inc."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-019-00726-y"},{"key":"e_1_2_9_7_1","volume-title":"BDI\u2010II, Beck Depression Inventory: Manual","author":"Beck A. 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