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Although previous studies have reported alterations in resting\u2010state brain activity in mTBI patients, the findings have been inconsistent, and the genetic basis of these changes has not been fully explored. A coordinate\u2010based voxel\u2010wise meta\u2010analysis was conducted to investigate resting\u2010state brain activity changes in mTBI, using nine datasets from 374 patients and 302 healthy controls (HCs). Transcription\u2010neuroimaging association analyses were performed using gene expression data from the Allen Human Brain Atlas (AHBA) to identify genes associated with brain activity alterations. Enrichment analyses were conducted to explore the biological functions of these genes. Compared to HCs, mTBI patients showed increased resting\u2010state brain activity in the left insula and right fusiform gyrus, and decreased activity in the bilateral middle frontal gyrus. Transcription\u2010neuroimaging association analyses identified 840 genes significantly correlated with these brain activity changes. Enrichment analyses revealed 15 biological processes significantly associated with the identified genes, primarily involving chemical synaptic transmission, multicellular organism development, and cell\u2013cell signaling. These genes were also enriched in Pnoc+, Ntsr+, and Cort+ neurons and were expressed predominantly from the late fetal to early adulthood stages. Our findings suggest that alterations in resting\u2010state brain activity in mTBI are linked to specific gene expression patterns, highlighting potential biological pathways involved in mTBI\u2010related brain changes.<\/jats:p>","DOI":"10.1002\/hbm.70259","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T08:20:06Z","timestamp":1749802806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resting\u2010State Brain Activity Changes and Their Genetic Correlates in Mild Traumatic Brain Injury"],"prefix":"10.1002","volume":"46","author":[{"given":"Lu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Geriatrics and Tianjin Geriatrics Institute Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of 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