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Around 10% of cases have a genetic basis, with the <jats:italic>C9orf72<\/jats:italic> hexanucleotide repeat expansion being the most common cause in individuals of European ancestry. Detecting early alterations in at\u2010risk individuals could aid in identifying biomarkers for timely diagnosis and intervention. In this study, we investigated electrophysiological changes in asymptomatic <jats:italic>C9orf72<\/jats:italic> mutation carriers using EEG, focusing on cognitive and motor networks, as these individuals are at risk of developing impairments in both domains. This study included 87 asymptomatic family members (AFM) of patients with familial <jats:italic>C9orf72<\/jats:italic> ALS, comprising 37 individuals carrying the pathological repeat expansion (C9+) and 50 without it (C9\u2212). High\u2010density EEG was recorded during the sustained attention to response task (SART), which is a Go\/NoGo paradigm that engages the frontoparietal and motor networks. Task performance was recorded and six behavioral measures were extracted: NoGo accuracy, Go accuracy, total accuracy, anticipation error, average response time, and response time variability. Analyses were conducted on EEG data in both sensor\u2010 and source\u2010space, using stimulus\u2010 and response\u2010locked data. The stimulus\u2010locked Go and NoGo data were analysed within two time windows: 180\u2013350\u2009ms (N2) and 300\u2013600\u2009ms (P3), while response\u2010locked Go data were analysed within a \u2212100 to 100\u2009ms time window. Linear mixed models were used to quantify differences between groups, incorporating familial pedigree to control for between\u2010subject dependencies. While the two groups did not significantly differ in any SART performance measures, EEG analyses revealed differences. During the stimulus\u2010locked N2, significant differences were observed in sensor\u2010space, primarily in central electrodes during both NoGo and Go conditions, with C9+ AFM exhibiting an increased negative potential. Source analysis confirmed these findings and localized the increased activity in the bilateral precuneus and superior parietal regions. Further analysis of the response\u2010locked data supported the involvement of the same posterior regions. No significant relationships were found between these EEG observations and SART performance. These findings provide the first evidence of EEG changes in AFM carrying the <jats:italic>C9orf72<\/jats:italic> repeat expansion. The observed functional changes in the parietal regions may reflect genotype\u2010related effects on the motor control network, potentially contributing to early pathophysiology. In contrast, clinical assessments and task performance did not differ between groups, suggesting that our EEG findings may hold promise as biomarkers for monitoring the risk of conversion to symptomatic disease and warrant further exploration to assess their predictive value for future symptom onset.<\/jats:p>","DOI":"10.1002\/hbm.70275","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T09:53:36Z","timestamp":1753437216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Altered EEG Response of the Parietal Network in Asymptomatic <i>C9orf72<\/i> Carriers"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-2876","authenticated-orcid":false,"given":"Stefan","family":"Dukic","sequence":"first","affiliation":[{"name":"Department of Neurology University Medical Center Utrecht Brain Center, Utrecht University  Utrecht the Netherlands"},{"name":"Academic Unit of Neurology School of Medicine, Trinity College Dublin, University of Dublin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-2351","authenticated-orcid":false,"given":"Kevin","family":"van Veenhuijzen","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Utrecht Brain Center, Utrecht University  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-3852","authenticated-orcid":false,"given":"Henk\u2010Jan","family":"Westeneng","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Utrecht Brain Center, Utrecht University  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9223-2241","authenticated-orcid":false,"given":"Roisin","family":"McMackin","sequence":"additional","affiliation":[{"name":"Academic Unit of Neurology School of Medicine, Trinity College Dublin, University of Dublin  Dublin Ireland"},{"name":"Discipline of Physiology School of Medicine, Trinity College Dublin, University of Dublin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-5967","authenticated-orcid":false,"given":"Ruben P. A.","family":"van Eijk","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Utrecht Brain Center, Utrecht University  Utrecht the Netherlands"},{"name":"Biostatistics &amp; Research Support Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6618-3573","authenticated-orcid":false,"given":"Boudewijn T. H. 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