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Beyond vessel patterns and dominances, the potential relation between the vascularization and the motor cortex thickness was studied. Twenty\u2010one healthy participants underwent 7\u2009T MRI scans to map arterial supply and motor cortex at 0.45\u2009mm isotropic resolution. The motor cortex vasculature was segmented manually with vessel\u2010specific labels. VDM was utilized to estimate the vessel\u2010specific supply regions and, subsequently, assess vessel patterns and dominances. Statistical tests were applied to test if the vasculature impacts mean motor cortical thickness estimates. Vessel patterns, that is the presence of supplying vessels, were classified as three\u2010, four\u2010, and five\u2010vessel patterns with a prevalence of 26.3%, 50.0%, and 23.7%, respectively. Vessel dominance, that is the ratio of supply volumes, of the ACA branches showed dominance of the pericallosal artery, callosomarginal artery, and equal contribution, in 34.2%, 34.2%, and 31.6% of the cases, respectively. For the MCA groups, the prevalence of precentral group dominance, central group dominances, and equal contribution was 13.2%, 34.2%, and 52.6%, respectively. Although the central and precentral groups were found in all hemispheres, the postcentral group was found in 28.9% of hemispheres with highly variable supply contribution. Statistical tests returned no significance for the effect of vessel patterns and dominances on the mean motor cortex thickness. With 7\u2009T MRI and VDM, the motor cortex vascularization can be assessed fully noninvasively and longitudinally while providing overall good concordance with previous post mortem studies. Our comprehensive analysis of arterial motor cortex vascularization showed considerable variability between hemispheres, rendering the usage of pattern\u2010specific atlases and analysis more suitable than single normative representations. The successful translation from post mortem to in\u00a0vivo enables the study of vascular reserve in disorders affecting the motor cortex, such as ALS, and can be translated to other brain regions and neurodegenerative diseases in the future.<\/jats:p>","DOI":"10.1002\/hbm.70311","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:25:40Z","timestamp":1754396740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing Arterial Patterns in the Motor Cortex With 7 Tesla Magnetic Resonance Imaging and Vessel Distance Mapping"],"prefix":"10.1002","volume":"46","author":[{"given":"Grazia","family":"Mietzner","sequence":"first","affiliation":[{"name":"Department of Neurology Otto Von Guericke University Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilli","family":"L\u00fcmkemann","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto Von Guericke University Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto Von Guericke University Magdeburg  Magdeburg Germany"},{"name":"German Center for Neurodegenerative Diseases  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jascha","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Department of Biomedical Magnetic Resonance Otto Von Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar","family":"Benramadan","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto Von Guericke University Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Al\u2010Dubai","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto Von Guericke University Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sciarra","sequence":"additional","affiliation":[{"name":"Department of Biomedical Magnetic Resonance Otto Von Guericke University  Magdeburg Germany"},{"name":"Medicine and Digitalization\u2014MedDigit, Medical Faculty, Univ. Dept. of Neurology Otto Von Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Knoll","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Magdeburg Germany"},{"name":"Institute of Cognitive Neurology and Dementia Research (IKND), Otto Von Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kuehn","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Magdeburg Germany"},{"name":"Hertie Institute for Clinical Brain Research (HIH)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Speck","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Magdeburg Germany"},{"name":"Department of Biomedical Magnetic Resonance Otto Von Guericke University  Magdeburg Germany"},{"name":"Leibniz Institute for Neurobiology  Magdeburg Germany"},{"name":"Center for Behavioral Brain Sciences  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto Von Guericke University Magdeburg  Magdeburg Germany"},{"name":"Department of Biomedical Magnetic Resonance Otto Von Guericke University  Magdeburg Germany"},{"name":"Center for Behavioral Brain Sciences  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5740-4522","authenticated-orcid":false,"given":"Hendrik","family":"Mattern","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Magdeburg Germany"},{"name":"Department of Biomedical Magnetic Resonance Otto Von Guericke University  Magdeburg Germany"},{"name":"Center for Behavioral Brain Sciences  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric Diffeomorphic Image Registration With Cross\u2010Correlation: Evaluating Automated Labeling of Elderly and Neurodegenerative Brain","volume":"12","author":"Avants B.","year":"2008","journal-title":"Medical Image Analysis"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1002\/hbm.24337","article-title":"The Morphology of the Human Cerebrovascular System","volume":"39","author":"Bernier M.","year":"2018","journal-title":"Human Brain Mapping"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71186","article-title":"Imaging of the Pial Arterial Vasculature of the Human Brain In\u00a0Vivo Using High\u2010Resolution 7T Time\u2010Of\u2010Flight Angiography","volume":"11","author":"Bollmann S.","year":"2022","journal-title":"eLife"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3171\/jns.1993.79.2.0256","article-title":"Microsurgical Anatomy of the Hippocampal Arteries","volume":"79","author":"Erdem A.","year":"1993","journal-title":"Journal of Neurosurgery"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1093\/brain\/awl158","article-title":"The Vascular Supply of the Functional Compartments of the Human Striatum","volume":"129","author":"Feekes J. 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