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While resting\u2010state fMRI (rs\u2010fMRI) has become a key tool in developmental neuroscience, few studies have jointly examined multiple functional metrics to comprehensively characterize typical brain maturation across youth. We analyzed rs\u2010fMRI data from 395 neurotypical participants aged 6\u201320\u2009years from the ABIDE I and II datasets. Voxel\u2010wise analyses were conducted using three complementary rs\u2010fMRI metrics: fractional amplitude of low\u2010frequency fluctuations (fALFF), regional homogeneity (ReHo), and voxel\u2010mirrored homotopic connectivity (VMHC). Data were harmonized across sites using ComBat and CovBat methods implemented in DPABI to minimize scanner\u2010related variability. Correlation analyses and ANOVA\/ANCOVAs were performed to examine developmental age effects. Our results revealed a general pattern of declining local and interhemispheric connectivity with increasing age, across all measures. fALFF decreases were most pronounced in the medial orbitofrontal, caudate, medial occipital cortex, and cerebellum (peak <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.210); ReHo showed reductions in the insula and caudate (peak <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.169); and VMHC declines were observed in the putamen, cerebellum, superior parietal lobules, and caudate (peak <jats:italic>r<\/jats:italic> range\u2009=\u2009\u22120.206 to \u22120.187). These findings outline a developmental trajectory characterized by increasing functional integration and network specialization from late childhood through adolescence. The combined use of fALFF, ReHo, and VMHC provides a robust multitechnical framework for characterizing typical brain development and offers a valuable benchmark for identifying developmental deviations in clinical populations.<\/jats:p>","DOI":"10.1002\/hbm.70320","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T14:05:39Z","timestamp":1756476339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hidden Rhythms of a Developing Brain: Multimetric rs\u2010fMRI Insights Into Typical Youth Maturation"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0143-3506","authenticated-orcid":false,"given":"Merida Galilea","family":"Tapia\u2010Medina","sequence":"first","affiliation":[{"name":"Department of Social Psychology and Quantitative Psychology University of Barcelona  Barcelona Spain"},{"name":"Institute of Complex Systems University of Barcelona  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