{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:48:10Z","timestamp":1792010890169,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Perinatal stroke is a vascular injury occurring early in life, often resulting in motor deficits (hemiplegic cerebral palsy\/HCP). Comorbidities may also include poor neuropsychological outcomes, such as deficits in memory. Previous studies have used resting state functional MRI (fMRI) to demonstrate that functional connectivity (FC) within hippocampal circuits is associated with memory function in typically developing controls (TDC) and in adults after stroke, but this is unexplored in perinatal stroke. Investigating links with visual memory function has the potential to inform prognosis and personalized cognitive rehabilitation strategies. This study aimed to quantify FC within hippocampal circuits of children and adolescents with perinatal stroke and associations with visual memory. We hypothesized that FC would differ between participant groups (AIS, PVI, TDC) and hemispheres (left vs. right stroke), and would correlate with visual memory function. Participants aged 6\u201319\u2009years with HCP and MRI\u2010confirmed unilateral perinatal stroke (<jats:italic>n<\/jats:italic>\u2009=\u200930) arterial ischemic stroke (AIS), <jats:italic>n<\/jats:italic>\u2009=\u200938 periventricular venous infarction (PVI) were recruited through the Alberta Perinatal Stroke Project and compared to <jats:italic>n<\/jats:italic>\u2009=\u200943 TDC. Resting fMRI volumes (150 volumes, TR\/TE\u2009=\u20092000\/30\u2009ms, voxels 3.6\u2009mm isotropic, 36 axial slices) were processed to compute FC values between memory\u2010related seeds (including bilateral hippocampi) using a standard pipeline in the CONN toolbox. Seed\u2010to\u2010voxel and seed\u2010to\u2010seed analyses computed FC with each hippocampus. Hemispheric and group differences in FC were examined. A subset of stroke participants (<jats:italic>n<\/jats:italic>\u2009=\u200946) completed visual memory testing via CNS Vital Signs (CNSVS), a computerized neurocognitive test battery. Partial correlations assessed associations between FC and visual memory function, factoring out age. We found hemispheric differences in FC within each group. Participants with left perinatal stroke showed greater FC between the hippocampus and lateral prefrontal cortex in the lesioned compared to non\u2010lesioned hemisphere. TDCs had higher hippocampal FC when compared to the lesioned hemisphere of stroke groups. For participants with right hemisphere stroke, associations were observed between hippocampal FC and visual memory function. We describe differences in bilateral hippocampal functional connectivity in children and adolescents with perinatal stroke that are associated with visual memory function. Our findings suggest that developmental plasticity may occur in the non\u2010lesioned hippocampus after perinatal stroke. These findings may inform our understanding of how visual memory function is affected after early unilateral brain injury and facilitate the development of novel therapies for individuals affected by perinatal stroke.<\/jats:p>","DOI":"10.1002\/hbm.70342","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T09:29:17Z","timestamp":1757323757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Functional Connectivity of Hippocampal Circuits and Visual Memory Function in Children and Adolescents With Perinatal Stroke"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8015-4423","authenticated-orcid":false,"given":"Armaan","family":"Dhanoa","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Calgary Pediatric Stroke Program, Alberta Children's Hospital  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nomazulu","family":"Dlamini","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy","family":"Fehlings","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kirton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Calgary Pediatric Stroke Program, Alberta Children's Hospital  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary  Calgary Alberta Canada"},{"name":"Department of Clinical Neurosciences University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-0542","authenticated-orcid":false,"given":"Helen L.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Calgary Pediatric Stroke Program, Alberta Children's Hospital  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104813"},{"key":"e_1_2_12_3_1","unstructured":"Arner M. 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