{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:14:03Z","timestamp":1760487243882,"version":"build-2065373602"},"reference-count":53,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01NS078680"],"award-info":[{"award-number":["2R01NS078680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We previously reported that a unilateral dorsal column lesion (DCL) at the cervical C4 level primarily reduces inter\u2010horn resting\u2010state functional connectivity (rsFC) measured by functional Magnetic Resonance Imaging (fMRI) in segments below the lesion. This study compares changes in rsFC from fMRI with changes in local field potential (LFP) coherence over an extended post\u2010injury period. High\u2010resolution fMRI and LFP data were acquired bilaterally in healthy monkeys and at 3\u2010 and 6\u2010months post\u2010lesion. At 3\u2009months post\u2010injury, tactile\u2010stimulus\u2010evoked LFP power in the dorsal horn was significantly weaker than in the healthy cord and non\u2010lesion side. LFP coherences increased on the lesion side for the dorsal\u2010to\u2010intermediate zone (D\u2010IGM) and dorsal\u2010to\u2010ventral (D\u2010V) pairs but decreased for the non\u2010lesion side D\u2010IGM. By 6\u2009months, stimulus\u2010evoked LFP power on the lesion side remained low. LFP coherences between dorsal\u2010to\u2010dorsal (D\u2010D), ventral\u2010to\u2010ventral (V\u2010V), and D\u2010V pairs on both the lesion and non\u2010lesion sides were significantly reduced relative to the healthy cord. Low\u2010frequency (delta, theta, and alpha) D\u2010IGM coherences on the lesion side, and high\u2010frequency (beta and gamma) coherences on the non\u2010lesion side, were also significantly weakened. Across specific inter\u2010horn pairs and time points, changes in LFP coherences and rsFC measures were weakly correlated. Measurements of inter\u2010horn correlations two segments caudal to the lesion level at C7 revealed distance\u2010dependent intraspinal connectivity changes following DCL. Post\u2010mortem histology confirmed a complete DCL in most animals (7\/9). The extent of the disruption of ascending sensory afferents, as assessed histologically, did not appear to correlate with the degree of LFP power reduction or rsFC changes at post\u2010injury time points. In summary, we observed temporally and spatially heterogeneous changes of fMRI correlations and LFP coherences within intraspinal circuits. fMRI rsFC and LFP coherences were not always concordant, with discrepancies depending on specific gray\u2010matter horns and intermediate\u2010zone pairs.<\/jats:p>","DOI":"10.1002\/hbm.70370","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T12:16:52Z","timestamp":1759148212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationships Between Intra\u2010Spinal Resting\u2010State Functional Connectivity and Electrophysiology Following Spinal Cord Injury"],"prefix":"10.1002","volume":"46","author":[{"given":"Pai\u2010Feng","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Imaging Science, Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie L.","family":"Reed","sequence":"additional","affiliation":[{"name":"Institute of Imaging Science, Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirban","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Institute of Imaging Science, Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arabinda","family":"Mishra","sequence":"additional","affiliation":[{"name":"Institute of Imaging Science, Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Imaging Science, Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Gore","sequence":"additional","affiliation":[{"name":"Institute of Imaging Science, Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-1925","authenticated-orcid":false,"given":"Li Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Imaging Science, Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.6.3580"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00251"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00177"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201034841\u20106"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.058"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.05.009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020352"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1048"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424106112"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1841\u201012.2012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201045302\u20100"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103127"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.48.4.396"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.10.036"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114150"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2024.115265"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/texcom\/tgaa052"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.034"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/4.2.166"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1979.11739553"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522\u20102594(200007)44:1<162::aid\u2010mrm23>3.0.co;2\u2010e"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2020.00031"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1361\u20108415(01)00036\u20106"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001045"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.07.024"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/10738584221101827"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414293111"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107793.1998.191bi.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurom.2022.09.001"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105364"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/156869"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2366\u201011.2011"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.05.058"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21061"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00084"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.08.015"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902420303"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/17590914211044000"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118391"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620520114"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105478"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000364913"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.137"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25488"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26756"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.04.023"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00137.2015"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2318\u201017.2017"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26905"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009485\u20103"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.12.011"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5877\u201011.2012"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.70370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:16:59Z","timestamp":1760404619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.70370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":53,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/hbm.70370"],"URL":"https:\/\/doi.org\/10.1002\/hbm.70370","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"type":"print","value":"1065-9471"},{"type":"electronic","value":"1097-0193"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70370"}}