{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:01:06Z","timestamp":1790740866087,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","award":["2016WS0529"],"award-info":[{"award-number":["2016WS0529"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH026"],"award-info":[{"award-number":["ZR2024MH026"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272072"],"award-info":[{"award-number":["82272072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Preeclampsia is a severe pregnancy complication that can cause brain injury, yet early detection of related cognitive deficits remains challenging. Therefore, in order to investigate alterations in choroid plexus volume (CPV) and susceptibility values of the choroid plexus (ChP) obtained from quantitative susceptibility mapping (QSM) in preeclampsia patients, we enrolled 281 participants, comprising 98 nonpregnant healthy controls (NPHC), 85 pregnant healthy controls (PHC), and 98 patients with preeclampsia. All participants were scanned on a 1.5\u2009T MR scanner. The results of clinical characteristics and cognitive tests were collected from all the participants. One\u2010way ANOVA tests were used to analyze the differences in CPV and susceptibility values of ChP among the three groups. Multiple linear regression analysis was used to find the factors that influenced CPV and its susceptibility values, as well as cognitive decline. Additionally, receiver operating characteristic (ROC) analysis was employed to evaluate the diagnostic performance of the two imaging measures. Preeclampsia patients exhibited smaller CPV and higher susceptibility values compared to the other groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Significant negative correlations were observed between body mass index (BMI), mean arterial pressure and CPV\/eTIV (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.100, 95% CI\u2009=\u2009\u22120.158\u2009~\u2009\u22120.042,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001;\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.022, 95% CI\u2009=\u2009\u22120.033\u2009~\u2009\u22120.011,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Additionally, significant positive correlations were observed between BMI (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.455, 95% CI\u2009=\u20090.125\u2009~\u20090.786,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007), mean arterial pressure (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.170, 95% CI\u2009=\u20090.107\u2009~\u20090.232,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), hemoglobin (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.152, 95% CI\u2009=\u20090.051\u2009~\u20090.254,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003) and susceptibility values of ChP. Furthermore, CPV\/eTIV and susceptibility values of ChP could be independent contributing factors of scores of TMT. The combination of CPV, susceptibility values of ChP, BMI and gestational week could distinguish preeclampsia from pregnant groups (AUC\u2009=\u20090.787, 95% CI\u2009=\u20090.722\u20130.853,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) as well as distinguish individuals with cognitive decline from preeclampsia patients (AUC\u2009=\u20090.737, 95% CI\u2009=\u20090.621\u20130.844,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). These findings indicate that smaller CPV and higher susceptibility values characterize preeclampsia and may serve as auxiliary indices for its diagnosis and related cognitive decline.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70397","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T16:17:55Z","timestamp":1763050675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Choroid Plexus Dysfunction and Cognitive Decline in Preeclampsia: Using\n                    <scp>T1WI<\/scp>\n                    Imaging, Quantitative Susceptibility Mapping and Deep\u2010Learning\u2010Based Segmentation"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6089-7160","authenticated-orcid":false,"given":"Boyao","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8320-5241","authenticated-orcid":false,"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C\u2010I\u2010R\u2010C)  Halle\u2010Jena\u2010Magdeburg Germany"},{"name":"Department of Psychiatry and Psychotherapy Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3228-6926","authenticated-orcid":false,"given":"Linfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-0608","authenticated-orcid":false,"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8054-5849","authenticated-orcid":false,"given":"Qihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Medical College of Cornell University  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0717-3228","authenticated-orcid":false,"given":"Zhenyu","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Medical Imaging Binzhou Medical University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9454-6424","authenticated-orcid":false,"given":"Xinxin","family":"Huo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5833-4285","authenticated-orcid":false,"given":"Fushuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medical Imaging Binzhou Medical University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9411-0145","authenticated-orcid":false,"given":"Yiwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7392-2566","authenticated-orcid":false,"given":"Pengcheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-625X","authenticated-orcid":false,"given":"Lingfei","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.02.020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.984929"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1141002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70553"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70022"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab029"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216680383"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.07.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.06.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-01008-z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13040"},{"issue":"1","key":"e_1_2_10_14_1","first-page":"552","article-title":"Choroid Plexus Volume, Amyloid Burden, and Cognition in the Alzheimer's Disease Continuum","volume":"16","author":"Jeong S. 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