{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:38:45Z","timestamp":1787585925237,"version":"build-2736575974"},"reference-count":100,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30\u2010AG066507"],"award-info":[{"award-number":["P30\u2010AG066507"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32\u2010AG027668"],"award-info":[{"award-number":["T32\u2010AG027668"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19\u2010AG033655"],"award-info":[{"award-number":["U19\u2010AG033655"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19\u2010AG065169"],"award-info":[{"award-number":["U19\u2010AG065169"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Structural changes in the cerebellum contribute to cognitive decline due to aging and Alzheimer's disease (AD). However, it is unclear whether age and AD pathology are associated with structural alterations in the cerebellum among cognitively unimpaired individuals and how these alterations relate to cognition. This study examined the association of age and cerebrospinal fluid (CSF) AD biomarkers (amyloid beta [A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    ], phosphorylated tau [p\u2010tau\n                    <jats:sub>181<\/jats:sub>\n                    ]) with cerebellar gray matter (GM) and white matter (WM) volumes and cerebellar WM microstructure, measured via magnetic resonance imaging (MRI) among 176 cognitively unimpaired middle\u2010aged and older adults (mean age\u2009=\u200966.70, range\u2009=\u200934\u201389). Cognition was measured with executive function and visuospatial composite scores. Older age was associated with lower cerebellar GM and WM volumes (\n                    <jats:italic>p<\/jats:italic>\n                    s\u2009&lt;\u20090.01) and greater mean diffusivity (MD) in the cerebellar peduncles (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). In contrast, more abnormal A\u03b2 levels were associated with lower MD in three regions of interest, including the middle cerebellar peduncle (MCP,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), a composite of superior, middle, and inferior peduncles (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), and within\u2010cerebellar WM (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Patterns were similar when comparing biomarker positive versus negative groups, particularly for the MCP. Further, lower MD in the peduncles and cerebellar WM was associated with better executive function and visuospatial composite scores (\n                    <jats:italic>p<\/jats:italic>\n                    s\u2009&lt;\u20090.05), whereas cerebellar volumetric measures were not related to cognition. Results suggest that older age is associated with microstructural and volumetric cerebellar GM and WM alterations. In contrast, A\u03b2 levels are associated with WM microstructural properties in cognitively unimpaired individuals. These findings highlight the importance of cerebellar WM microstructure to cognition and are consistent with, and expand on, previous reports that have linked more abnormal amyloid levels to WM microstructure in cerebral tracts. They also suggest that cerebellar WM alterations may be markers of preclinical AD.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70398","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:52:36Z","timestamp":1762170756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebellar White Matter Microstructure Is Associated With Age, Cerebrospinal Fluid Amyloid Beta Levels, and Cognition in Cognitively Unimpaired Older Adults"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-0411","authenticated-orcid":false,"given":"Elizabeth R.","family":"Paitel","sequence":"first","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Pettigrew","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Callow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Moghekar","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-002X","authenticated-orcid":false,"given":"Andreia V.","family":"Faria","sequence":"additional","affiliation":[{"name":"Department of Radiology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1200-8611","authenticated-orcid":false,"given":"Kenichi","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Radiology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Soldan","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.09.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720501108140910121920"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10884"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010023\u201001577\u20107"},{"key":"e_1_2_9_7_1","first-page":"45","volume-title":"Handbook of Clinical Neurology","author":"Ashida R.","year":"2018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14734220601169707"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565641003696775"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26353"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1995.tb02031.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.11.026"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20872"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104639"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010013\u20100481\u2010z"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.02.011"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2023.01.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.044"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.09.041"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.02.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.057"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12124"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.12.001"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00220"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.01.009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010023\u201002869\u20109"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102605"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102017\u2010315607"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160865"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102749"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201018198\u2010x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.095763"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200953"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201051892\u20107.00001\u20102"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1424"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24774"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.02.012"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010013\u20100543\u20102"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00396"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70291\u20100"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx194"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21412"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197\u20104580(01)00217\u20102"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2005.08.004"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.081"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1162\/nol_a_00098"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.08.058"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22775"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurop.2021.12.002"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160722"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010019\u201001099\u20101"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.08.003"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317510382892"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317519859200"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/737846"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/14734220701230870"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1109\/MCSE.2016.93"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004870"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.002"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.10.026"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.14395"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2025.04.005"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww015"},{"key":"e_1_2_9_65_1","volume-title":"Statistical Parametric Mapping: The Analysis of Functional Brain Images","author":"Penny W. D.","year":"2011"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12374"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.02.001"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.03.020"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi044"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1958.8.3.271"},{"key":"e_1_2_9_71_1","first-page":"286","article-title":"L'examen psychologique dans les cas d'encephalopathie traumatique","volume":"28","author":"Rey A.","year":"1941","journal-title":"Archives de Psychologie"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1363"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010024\u201000599\u2010y"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww064"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.07.005"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010070918\u2010050258"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103639.2010.00469.x"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104589"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00530"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00132\/full"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1078448"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010011\u20100260\u20107"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.039"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.04.031"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.645171"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096985"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2007.12.002"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00430"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(13)70044\u20109"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-476X(81)90035-7"},{"key":"e_1_2_9_93_1","volume-title":"Wechsler Memory Scale\u2010Revised","author":"Wechsler D.","year":"1987"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(98)01279\u20107"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.12.009"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010150049"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00143"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.638"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010016\u20100813\u2010x"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.02.05.636737"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00143"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.70398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.70398","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.70398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:00:22Z","timestamp":1770912022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.70398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":100,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/hbm.70398"],"URL":"https:\/\/doi.org\/10.1002\/hbm.70398","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70398"}}