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A binary (+\/\u2212) label is assigned for each pathology (A, T, N) based on its presence or absence as determined by imaging or fluid biomarkers. Using imaging, neurodegeneration is confirmed by either structural MRI (indicating atrophy) or 18F\u2010FDG PET (indicating hypometabolism), implicitly assuming that both modalities identify equivalent pathology. Preliminary evidence suggests that atrophy and hypometabolism do not spatially co\u2010localize and are likely caused by distinct underlying pathologies. Further, while MRI is widely available, many sites lack access to PET. Recent evidence indicates that hemodynamic indices, identified via functional MRI or SPECT, may be spatially concordant with hypometabolism identified by 18F\u2010FDG\u2010PET and able to serve as reliable proxies. 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