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This study analyses neuroimaging data from AOS in order to propose and computationally test a mechanistic explanation of how the lesion leads to the characteristic of altered lexical stress in the disorder. Neuroimaging data from 31 participants with left hemisphere stroke (15 AOS) were reanalysed to guide a \u2018lesioned\u2019 version of the bilateral GODIVA neuro\u2010computational model of speech production. Structural MRI and resting\u2010state functional MRI measurements were used to decide the model's lesion extent and atypical neural processing, respectively. The \u2018lesioned\u2019 model was compared with a neurotypical model on the production of an exemplar utterance with different linguistic contexts. Analyses revealed the average lesion in the AOS participants extended over 22.25% of the left anterior ventral precentral sulcus. Functional connectivity in AOS was reduced between the lateral part of that region and the right motor cortex, as well as between the left and right motor cortices themselves. The version of the model that we altered in line with these findings produced lengthening of the second of two consecutive short syllables. The lengthened syllable was a word\u2010initial unstressed syllable, and consequently, its contrastiveness with the adjacent stressed syllable of the word was reduced. The agreement between simulation results and previously reported acoustic measurements from actual AOS patients lends support to our mechanistic explanation. In conclusion, simulations of the GODIVA model provided empirical support for a mechanistic explanation indicating permanent sub\u2010threshold cortical activity in AOS. As a result, the speech system becomes biased away from a motor control strategy based on motor programs and toward a strategy based on sensory feedback. This both lengthens brief syllables and interferes with the mechanism to shift between syllables, ultimately altering lexical stress. Analysis of the model's neural dynamics suggests the explanation can be generalised to various contexts where lexical stress is altered in AOS.<\/jats:p>","DOI":"10.1002\/hbm.70412","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T11:47:41Z","timestamp":1765453661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Imaging\u2010Guided Neural Model Explains Lexical Stress Alteration in Acquired Apraxia of Speech"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0090-271X","authenticated-orcid":false,"given":"Oren","family":"Civier","sequence":"first","affiliation":[{"name":"Swinburne University of Technology  Melbourne Victoria Australia"},{"name":"Australian National Imaging Facility Swinburne Node  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Ramage","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders University of New Hampshire  Durham New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Tourville","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences Boston University  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald A.","family":"Robin","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders University of New Hampshire  Durham New Hampshire USA"},{"name":"Interdisciplinary Program in Neuroscience and Behavior University of New Hampshire  Durham New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank H.","family":"Guenther","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences Boston University  Boston Massachusetts USA"},{"name":"Department of Biomedical Engineering Boston University  Boston Massachusetts USA"},{"name":"The Picower Institute for Learning and Memory Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9917-5390","authenticated-orcid":false,"given":"Kirrie J.","family":"Ballard","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown New South Wales Australia"},{"name":"The Brain and Mind Centre, The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2016.01.009"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2004.02.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2015.12.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3200\/JMBR.39.1.19-28"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00892"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1044\/2017_JSLHR-S-16-0443"},{"key":"e_1_2_9_9_1","unstructured":"Bauman J. 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