{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:27:49Z","timestamp":1765610869887,"version":"3.48.0"},"reference-count":78,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R322\u20102019\u20102311"],"award-info":[{"award-number":["R322\u20102019\u20102311"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015572","name":"National Imaging Facility","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015572","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013102","name":"Centre of Excellence for Integrative Brain Function, Australian Research Council","doi-asserted-by":"publisher","award":["ARC CE140100007"],"award-info":[{"award-number":["ARC CE140100007"]}],"id":[{"id":"10.13039\/100013102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Structural deficits in white matter fibre have been linked to psychosis. However, it remains unclear whether these aberrations are present in individuals that experience non\u2010clinical psychotic\u2010like experiences, predating illness onset. While previous research demonstrates that alterations in white matter in schizotypy are consistent with those in clinical psychosis, these studies often dichotomise healthy samples into high and low schizotypy, which may reduce statistical sensitivity. Previous research is also confounded by the investigation of diffusion MRI parameters that fail to account for complex crossing fibre populations. In this work, we treat psychotic\u2010like experiences as a continuous variable, and applied Fixel\u2010Based Analysis (FBA), a framework for investigating microstructural and morphological effects in brain white matter using diffusion\u2010weighted imaging data. Across two independent cohorts of healthy participants with varied psychotic\u2010like experiences including data from the IMAGEN consortium (Study 1\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200941; Study 2\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091098), we hypothesized that greater psychotic\u2010like experiences would be associated with FBA metrics sensitive to microstructural fibre density and\/or cross\u2010sectional morphological effects. Contrary to our hypothesis, we did not find significant correlations between psychotic\u2010like experiences and FBA metrics across either dataset (FWE\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Bayesian analysis of tract\u2010aggregated data showed substantial evidence of no association (Bayes factor &lt;\u20091\/3) between psychotic\u2010like experiences and fibre density, nor cross\u2010sectional morphology, across several white matter tracts of interest, pre\u2010defined from prior neuroimaging literature. These findings suggest that the relationship between non\u2010clinical psychotic\u2010like experiences and white matter microstructure may not be as robust as previously thought. This raises the possibility that white matter alterations across the psychosis spectrum echo clinical diagnostic thresholding, with observable effects in clinical but not sub\u2010clinical presentations. Our findings show no association between whole\u2010brain fibre\u2010specific properties of white matter microstructure and sub\u2010clinical psychotic\u2010like experiences. Further, we show evidence for the lack of an association within tract\u2010aggregated fibre\u2010specific metrics. Future research should integrate longitudinal designs to explore whether fibre\u2010specific white matter attributes provide clinically meaningful insight into the risk of psychosis onset.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70414","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T11:21:09Z","timestamp":1765365669000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychotic\u2010Like Experiences and White Matter Microstructure: A Fixel\u2010Based Analysis Approach With Robust Replication Across Two Cohorts"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-6682","authenticated-orcid":false,"given":"Isabella","family":"Goodwin","sequence":"first","affiliation":[{"name":"Melbourne School of Psychological Sciences, The University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kit Melissa","family":"Larsen","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arshiya","family":"Sangchooli","sequence":"additional","affiliation":[{"name":"Melbourne School of Psychological Sciences, The University of Melbourne  Melbourne Australia"},{"name":"Turner Institute for Brain and Mental Health, Monash University  Heidelberg Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Smith","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscienace and Mental Health  Heidelberg Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Banaschewski","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, German Center for Mental Health (DZPG)  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth J.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging Institute of Psychiatry, Psychology &amp; Neuroscience  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun L. W.","family":"Bokde","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Br\u00fchl","sequence":"additional","affiliation":[{"name":"Physikalisch\u2010Technische Bundesanstalt (PTB)  Braunschweig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvane","family":"Desrivi\u00e8res","sequence":"additional","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &amp; Neuroscience, King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Garavan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology University of Vermont  Burlington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny","family":"Gowland","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Grigis","sequence":"additional","affiliation":[{"name":"NeuroSpin, CEA  Gif\u2010sur\u2010Yvette France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Heinz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy CCM Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t Zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herve","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"Institut Des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, UMR 5293, CNRS, CEA, Universit\u00e9 de Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Luc","family":"Martinot","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherce M\u00e9dicale, INSERM U A10 \u201cTrajectoires d\u00e9veloppementales &amp; Psychiatrie\u201d, University Paris\u2010Saclay, Ecole Normale Sup\u00e9rieure Paris\u2010Saclay, CNRS  Gif\u2010sur\u2010Yvette France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Laure Paill\u00e8re","family":"Martinot","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherce M\u00e9dicale, INSERM U A10 \u201cTrajectoires d\u00e9veloppementales &amp; Psychiatrie\u201d, University Paris\u2010Saclay, Ecole Normale Sup\u00e9rieure Paris\u2010Saclay, CNRS  Gif\u2010sur\u2010Yvette France"},{"name":"AP\u2010HP. Sorbonne Universit\u00e9, Department of Child and Adolescent Psychiatry Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Artiges","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherce M\u00e9dicale, INSERM U A10 \u201cTrajectoires d\u00e9veloppementales &amp; Psychiatrie\u201d, University Paris\u2010Saclay, Ecole Normale Sup\u00e9rieure Paris\u2010Saclay, CNRS  Gif\u2010sur\u2010Yvette France"},{"name":"Psychiatry Department EPS Barth\u00e9l\u00e9my Durand  Etampes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7796-8234","authenticated-orcid":false,"given":"Frauke","family":"Nees","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, German Center for 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