{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:27:50Z","timestamp":1765610870676,"version":"3.48.0"},"reference-count":45,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008130","name":"Pusan National University Hospital","doi-asserted-by":"publisher","award":["20240043"],"award-info":[{"award-number":["20240043"]}],"id":[{"id":"10.13039\/501100008130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The dopamine transporter (DAT) mediates the reuptake of extracellular dopamine into presynaptic neurons. We investigated the effects of glucose loading on the striatal DAT in healthy young adults who underwent\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FP\u2010CIT PET scans and completed a sweet taste questionnaire (STQ). Thirty\u2010five healthy participants were enrolled in this study. Each participant visited the institution three times for three brain PET scans (two\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FP\u2010CIT PET scans after the infusion of glucose or placebo and one\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010Fluorodeoxyglucose PET scan). All participants underwent the 12\u2010item self\u2010reporting STQ to evaluate their reactions to eating sweet foods, cravings for sweet foods, and degree of control over eating sweet foods (STQ 1: sensitivity to the mood\u2010altering effect of sweet foods, and STQ 2: impaired control over eating sweet foods). In the caudate, glucose\u2010loaded DAT availability was significantly higher than placebo\u2010loaded DAT availability, and in the putamen, there was a trend toward higher DAT availability following glucose loading. The STQ was consistently positively related to glucose\u2010loaded DAT availability, not with placebo\u2010loaded DAT availability. In conclusion, changes in striatal DAT availability after glucose loading suggest an association with attitudes toward sweet foods in healthy young males. This may indicate that individuals with higher DAT availability after glucose loading experience rapid clearance of synaptic dopamine after consuming sweet foods, potentially leading to a desire for additional sweet foods.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70426","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T14:23:59Z","timestamp":1764771839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Change of Dopamine Transporter After Glucose Loading Is Associated With an Individual's Attitude Toward Sweet Foods in Healthy Young Males"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-1894","authenticated-orcid":false,"given":"Kyoungjune","family":"Pak","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Biomedical Research Institute Pusan National University Hospital  Busan Republic of 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