{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:20:54Z","timestamp":1789518054680,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["24\u201012183M"],"award-info":[{"award-number":["24\u201012183M"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU20J\u201004\u201000022"],"award-info":[{"award-number":["NU20J\u201004\u201000022"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LM2018129"],"award-info":[{"award-number":["LM2018129"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LM2023069"],"award-info":[{"award-number":["LM2023069"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["857560"],"award-info":[{"award-number":["857560"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014405","name":"Centre for Addiction and Mental Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alterations in mitochondrial DNA (mtDNA) have been associated with worse cognitive abilities in older adults and premature epigenetic aging in young adulthood. However, it is not clear how mitochondrial dysfunction affects brain function in young adulthood and whether cognition\u2010related networks might be most affected. We tested whether mtDNA functional impact (FI) score might map onto specific patterns of between\u2010network functional connectivity in young adults from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC). We also tested whether these relationships might be mediated by accelerated epigenetic aging, calculated using Horvath's epigenetic clock, CheekAge clock, and AltumAge clock. General connectivity method was used as a reliable marker of individual differences in brain function. We showed that a greater mtDNA FI score was associated with lower connectivity between the dorsal attention and language networks (beta\u2009=\u2009\u22120.41,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0007, Adj\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.15) and that there was suggestive evidence that this relationship might be mediated by accelerated epigenetic aging calculated using Horvath's epigenetic clock in young adulthood (ab\u2009=\u2009\u22120.061, SE\u2009=\u20090.04, 95% CI [\u22120.163; 0.001], 90% CI [\u22120.142; \u22120.002]). These findings were independent of sex, current BMI, and current substance use. Overall, we conclude that individuals with a greater mtDNA FI score might be at greater risk of experiencing worse attention to relevant linguistic inputs, greater difficulties with speech comprehension, and verbal working memory.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70447","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T09:24:31Z","timestamp":1767345871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Functional Impact Score of Mitochondrial Variants and Its Relationship With Functional Connectivity of the Brain: Potential Origins of Premature Aging in Young Adulthood"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-9939","authenticated-orcid":false,"given":"Klara","family":"Mareckova","sequence":"first","affiliation":[{"name":"Brain and Mind Research, Central European Institute of Technology, Masaryk University (CEITEC MU)  Brno Czech Republic"},{"name":"First Department of Neurology St. Anne's University Hospital and Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Mendes\u2010Silva","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH)  Toronto ON Canada"},{"name":"Tanenbaum Centre for Pharmacogenetics, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Department of Psychiatry University of Saskatchewan  Saskatoon SK Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radek","family":"Mare\u010dek","sequence":"additional","affiliation":[{"name":"Brain and Mind Research, Central European Institute of Technology, Masaryk University (CEITEC MU)  Brno Czech Republic"},{"name":"First Department of Neurology St. Anne's University Hospital and Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Jord\u00e1nek","sequence":"additional","affiliation":[{"name":"Brain and Mind Research, Central European Institute of Technology, Masaryk University (CEITEC MU)  Brno Czech Republic"},{"name":"First Department of Neurology St. Anne's University Hospital and Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pa\u010d\u00ednkov\u00e1","sequence":"additional","affiliation":[{"name":"Brain and Mind Research, Central European Institute of Technology, Masaryk University (CEITEC MU)  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Kl\u00e1nov\u00e1","sequence":"additional","affiliation":[{"name":"RECETOX, Faculty of Science, MU  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa F.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH)  Toronto ON Canada"},{"name":"Tanenbaum Centre for Pharmacogenetics, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya S.","family":"Nikolova","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH)  Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0730\u2010725x(00)00190\u20109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.11.109"},{"key":"e_1_2_11_4_1","volume-title":"The Handbook of Aging and Cognition","author":"Craik F.","year":"2000"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514\u2010022\u201000085\u2010y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26119"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010022\u201003196\u20100"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu733"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.068"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705843104"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2010.09.013"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010024\u201000802\u20104"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1616"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18933"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191153"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.07.010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115887"},{"key":"e_1_2_11_18_1","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis. Second Edition. A Regression\u2010Based Approach","author":"Hayes A. F.","year":"2018"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102013\u201014\u201010\u2010r115"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2354"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acu016"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj010"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.10.006"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000403)96:2<182::AID-AJMG12>3.0.CO;2-Q"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00173-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2015.05.015"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp528"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010020\u201000976\u20105"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.12.029"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1385\/nmm:5:2:147"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010024\u201002941\u20109"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010025\u201003235\u20104"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1215957"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291725000042"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102458"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.7.1058"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.06.092"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1427.007"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.032"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00067.2014"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.03.006"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321881111"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw091"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.048"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40200\u2010020\u201000679\u2010x"},{"key":"e_1_2_11_47_1","volume-title":"Cognitive Aging: A Primer","author":"Sanfey A.","year":"2000"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010012\u20100980\u2010x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010024\u201001094\u20103"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102350\u201014\u201073"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13102044"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-023-00307-6"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201096120\u20105"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts680"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx513"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.81"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303346110"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201000983\u20103"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858413494269"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.10.025"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.70447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.70447","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.70447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:54:20Z","timestamp":1768478060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.70447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/hbm.70447"],"URL":"https:\/\/doi.org\/10.1002\/hbm.70447","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70447"}}