{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:33:56Z","timestamp":1772998436190,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001061","name":"Rebecca L. Cooper Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2026,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fibromyalgia is associated with elevated levels of comorbid anxiety and depression, together impacting brain morphology possibly reflecting common underlying biological processes. The present study aims to determine the difference in regional myelination in females with fibromyalgia compared with females who do not experience chronic pain and to determine the role of the severity of comorbid anxiety and depressive symptoms experienced to mediate this difference in brain myelination. Thirty\u2010three females with and 33 females without (controls) fibromyalgia were included, for which the severity of depressive and anxiety symptoms was recorded using the Hamilton Anxiety\/Depression Rating scales (HAMA\/HAMD). Whole\u2010brain three\u2010dimensional T1\u2010weighted (T1w) and T2\u2010weighted (T2w) magnetic resonance imaging scans were collected, and T1w\/T2w ratio (myelin maps) was derived. Mediation analyses were performed with anxiety and depressive symptoms as mediators of the T1w\/T2w ratio differences among the groups. Compared with the control group, the fibromyalgia group had lower T1w\/T2w values in the left cerebellar lobule VI (\n                    <jats:italic>pFWEc<\/jats:italic>\n                    \u2009=\u20090.030) and left cerebellar lobule VIII (\n                    <jats:italic>pFWEc<\/jats:italic>\n                    \u2009=\u20090.029). These T1w\/T2w values were significantly negatively associated with the severity of anxiety and depressive symptoms (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Mediation analyses indicated that the severity of anxiety (but not depressive) symptoms mediated the group difference in T1w\/T2w values in cerebellar lobule VI (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012), but not VIII (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.813). Lowered cerebellar myelination may reflect chronic states of low\u2010grade inflammation, resulting from the long\u2010term consequences of living with fibromyalgia and related anxiety and depressive symptoms. This remains speculative, and future studies integrating peripheral biological markers of inflammation are warranted to confirm this interpretation.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70467","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:55:45Z","timestamp":1771224945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebellar Tissue Properties Alterations in Fibromyalgia: A T1w\/T2w Ratio Study"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-7139","authenticated-orcid":false,"given":"Yann","family":"Quid\u00e9","sequence":"first","affiliation":[{"name":"NeuroRecovery Research Hub, School of Psychology The University of New South Wales (UNSW) Sydney  Sydney New South Wales Australia"},{"name":"Centre for Pain IMPACT, Neuroscience Research Australia  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9613-9845","authenticated-orcid":false,"given":"Sylvia M.","family":"Gustin","sequence":"additional","affiliation":[{"name":"NeuroRecovery Research Hub, School of Psychology The University of New South Wales (UNSW) Sydney  Sydney New South Wales Australia"},{"name":"Centre for Pain IMPACT, Neuroscience Research Australia  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2470547017704763"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2541\u201004.2004"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v67n0807"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u2010981\u201019\u20107376\u20105_16"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597\u2010022\u201001677\u20109"},{"key":"e_1_2_13_7_1","doi-asserted-by":"crossref","unstructured":"Balducci T. J.Rasgado\u2010Toledo A.Valencia M. J.vanTol A.Aleman andE. A.Garza\u2010Villarreal.2022b.A Behavioral Clinical and Brain Imaging Dataset With Focus on Emotion Regulation of Females With Fibromyalgia.","DOI":"10.1038\/s41597-022-01677-9"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16142313"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12162028"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20101781(94)90110\u20104"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181a32da0"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.01.001"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506879"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.08.015"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.760721"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054722"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010015\u20109485\u20102"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.056"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.045"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2002.tb04229.x"},{"issue":"2","key":"e_1_2_13_21_1","first-page":"88","article-title":"Fibromyalgia and Psychiatric Disorders","volume":"78","author":"Fietta P.","year":"2007","journal-title":"Acta Biomed"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100675\u20100"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00671"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2180\u201011.2011"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2019.100177"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12968"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40673\u2010018\u20100083\u20100"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1868\u201009.2009"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13030\u2010023\u201000293\u20102"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1304"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22194"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.02.022"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010024\u201002768\u20102"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2639"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.03.015"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103959(99)00300\u20100"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.5"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165\u20100270(96)00148\u20103"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010023\u201003064\u20100"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.38"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010022\u201000873\u20106"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.10.003"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.04.011"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.039"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060515587578"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201039199\u2010x"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2316"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.27"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20140"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.012"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203755"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.70467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.70467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.70467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:50:10Z","timestamp":1772988610000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.70467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2,15]]}},"alternative-id":["10.1002\/hbm.70467"],"URL":"https:\/\/doi.org\/10.1002\/hbm.70467","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,15]]},"assertion":[{"value":"2025-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70467"}}